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Targeting mutant p53: Evaluation of novel anti-p53 monoclonal antibodies as diagnostic tools.
Sci Rep
January 2025
Department of Microbiology, Tumor and Cell Biology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
About 50% of all cancers carry a mutation in p53 that impairs its tumor suppressor function. The p53 missense mutation p53 (p53 in mice) is a hotspot mutation in various cancer types. Therefore, monoclonal antibodies selectively targeting clinically relevant mutations like p53 could prove immensely value.
View Article and Find Full Text PDFEdge-Energy-Driven Growth of Monolayer MnI Islands on Ag(111): High-Resolution Imaging and Theoretical Analysis.
ACS Nano
January 2025
Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam-Golm, Germany.
The reduced dimensionality of thin transition metal dihalide films on single-crystal surfaces unlocks a diverse range of magnetic and electronic properties. However, achieving stoichiometric monolayer islands requires precise control over the growth conditions. In this study, we employ scanning probe microscopy to investigate the growth of MnI on Ag(111) via single-crucible evaporation.
View Article and Find Full Text PDFPhysical origin and control of exciton spatial localization in high-κ MOene monolayers under external perturbations.
J Phys Condens Matter
January 2025
Institute of Nano Science and Technology, Sector 81, Knowledge City, Manauli, Mohali, Mohali, Punjab, 140306, INDIA.
Two-dimensional (2D) materials hold great promise for the next-generation optoelectronics applications, many of which, including solar cell, rely on the efficient dissociation of exciton into free charge carriers. However, photoexcitation in atomically thin 2D semiconductors typically produces exciton with a binding energy of ~500 meV, an order of magnitude larger than thermal energy at room temperature. This inefficient exciton dissociation can limit the efficiency of photovoltaics.
View Article and Find Full Text PDFUsefulness of Dual-Energy CT for Differentiating Hemorrhage From Iodine Extravasation in Meningiomas After Preoperative Embolization.
J Comput Assist Tomogr
November 2024
From the Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto.
Objective: Discriminating between hemorrhage and iodine extravasation can pose challenges in conventional computed tomography (CCT) images following preoperative embolization for meningioma. This study aimed to assess the efficacy of dual-energy computed tomography (DECT) in differentiating hemorrhage from iodine extravasation after preoperative embolization for meningioma.
Methods: Twenty-one consecutive meningioma patients who underwent CCT before and DECT immediately after preoperative embolization were included in this study.
Development and Clinical Evaluation of a Contrast Optimizer for Contrast-Enhanced CT Imaging of the Liver.
J Comput Assist Tomogr
November 2024
From the Carl E. Ravin Advanced Imaging Labs, Center for Virtual Imaging Trials, Department of Radiology.
Objective: Patient characteristics, iodine injection, and scanning parameters can impact the quality and consistency of contrast enhancement of hepatic parenchyma in CT imaging. Improving the consistency and adequacy of contrast enhancement can enhance diagnostic accuracy and reduce clinical practice variability, with added positive implications for safety and cost-effectiveness in the use of contrast medium. We developed a clinical tool that uses patient attributes (height, weight, sex, age) to predict hepatic enhancement and suggest alternative injection/scanning parameters to optimize the procedure.
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