We have reported a 38-year-old female who did not show clinical seizures during continuous spikes in the left occipital area over a period of 18 years. As to the neurological findings, visual disturbance, optic nerve atrophy and right hemianopsia were almost always present. The low density area distributing from the left occipital area to the left temporal one on the CT revealed to be porencephaly. From the clinical findings obtained in this case, the lesion responsible for the occipital continuous spikes could be ascribed to be functional abnormality of the visual pathway connecting the left lateral geniculate body with the left occipital cortex.
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http://dx.doi.org/10.1111/j.1440-1819.1992.tb00544.x | DOI Listing |
J Am Chem Soc
January 2025
Molecular Sensing and Imaging Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
Nanopore technology holds great potential for single-molecule identification. However, extracting meaningful features from ionic current signals and understanding the molecular mechanisms underlying the specific features remain unresolved. In this study, we uncovered a distinctive ionic current pattern in a K238Q aerolysin nanopore, characterized by transient spikes superimposed on two stable transition states.
View Article and Find Full Text PDFCureus
November 2024
Department of Epileptology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JPN.
Herein, we present a case of idiopathic generalized epilepsy (IGE) manifesting as de novo late-onset absence status epilepticus (ASE) following mild coronavirus disease 2019 (COVID-19). A woman in her 40s presented with persistent 3-5.5 Hz generalized spike-wave complexes (SWCs) on electroencephalography (EEG).
View Article and Find Full Text PDFAnn Epidemiol
December 2024
Bureau of Epidemiology Services, Center for Population Health Data Science, NYC Department of Health & Mental Hygiene, 42-09 28th St, Queens, NY 11101, USA.
Purpose: Between April-October 2021, the New York City (NYC) Health Department conducted a serosurvey to assess prevalence of SARS-CoV-2 antibodies in NYC adults as part of continued COVID-19 surveillance efforts.
Methods: Whole blood specimens were collected from 1035 adult NYC residents recruited from an annual population-based health surveillance survey. Specimens were tested for the presence of anti-SARS-CoV-2 spike protein (anti-spike) and anti-SARS-CoV-2 nucleocapsid protein (anti-nucleocapsid) antibodies.
Neural Netw
December 2024
School of Artificial Intelligence, Anhui University, Hefei, 230601, Anhui, China; Engineering Research Center of Autonomous Unmanned System Technology, Ministry of Education, Hefei, 230601, Anhui, China; Anhui Provincial Engineering Research Center for Unmanned Systems and Intelligent Technology, Hefei, 230601, Anhui, China; School of Automation, Southeast University, Nanjing, 211189, Jiangsu, China. Electronic address:
Deep reinforcement learning (DRL) exploits the powerful representational capabilities of deep neural networks (DNNs) and has achieved significant success. However, compared to DNNs, spiking neural networks (SNNs), which operate on binary signals, more closely resemble the biological characteristics of efficient learning observed in the brain. In SNNs, spiking neurons exhibit complex dynamic characteristics and learn based on principles of biological plasticity.
View Article and Find Full Text PDFVirology
December 2024
Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Departamento de Biotecnología y Bioingeniería, Av. Instituto Politécnico Nacional 2508, Mexico City, 07360, Mexico; CINVESTAV, Programa de Doctorado Transdisciplinario en Desarrollo Científico y Tecnológico para la Sociedad, Mexico. Electronic address:
COVID-19 infections continue due to accessibility barriers to vaccines and the emergence of SARS-CoV-2 variants. An effective, safe, accessible, and broad-spectrum vaccine is still needed to control the disease. We developed a multivalent protein subunit vaccine comprising antigens designed from a non-N-glycosylated region of the receptor-binding domain of the spike protein of SARS-CoV-2.
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