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Characterization of Choerospondias axillaris polysaccharide‑iron (III) complex and its effect on iron deficiency anemia mice.
Int J Biol Macromol
January 2025
College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address:
Iron deficiency anemia (IDA) is a prevalent nutritional deficiency problem. This study aimed to investigate the characteristics of Choerospondias axillaris polysaccharide-Fe (III) complex and its effect on IDA mice. CAP-Fe (III) complex was synthesized by co-thermal synthesis method with an iron content of 27.
View Article and Find Full Text PDFHb Monza: A novel extensive HBB duplication with preserved α-β subunit interaction and unstable hemoglobin phenotype.
Med
December 2024
Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; Hematology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Background: Unstable hemoglobins are caused by single amino acid substitutions in the HBB gene, often affecting key histidine residues, leading to protein destabilization and hemolytic crises. In contrast, long HBB variants, exceeding 20 bp, are rare and associated with a β-thalassemia phenotype due to disrupted α-β chain interactions. We describe a family wherein four of six members carry a novel 23-amino-acid in-frame duplication of HBB (c.
View Article and Find Full Text PDFEvaluation of Three Mutations in Codon 385 of Glucose-6-Phosphate Dehydrogenase via Biochemical and In Silico Analysis.
Int J Mol Sci
November 2024
Laboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy that affects approximately 500 million people worldwide. A great number of mutations in the gene have been described. However, three class A G6PD variants known as G6PD Tomah (C385R), G6PD Kangnam (C385G), and G6PD Madrid (C385W) have been reported to be clinically important due to their associations with severe clinical manifestations such as hemolytic anemia.
View Article and Find Full Text PDFCharacterization of food color additives and evaluation of their acute toxicity in Wistar albino rats.
Vet World
October 2024
Department of Microbiology, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.
Article Synopsis
- The study investigates the toxicity and chemical nature of commercial food dyes versus standard dyes, focusing on potential health risks like anemia and cancer.
- Three food color additives (Sunset Yellow, Tartrazine, and Carmoisine) were analyzed using FTIR spectroscopy and lethal dose tests in Wistar albino rats, with doses ranging from 2 to 15 g/kg body weight.
- Results showed commercial dyes generally had lower melting points and were more toxic, with signs of adverse effects noted at the highest dose, highlighting differences in purity and composition compared to standard dyes.
FT-4202, a selective pyruvate kinase R activator for sickle cell disease.
Exp Hematol
January 2025
Forma Therapeutics, Inc., Watertown, MA.
Anemia in patients with sickle cell disease (SCD) increases 2,3-diphosphoglycerate (2,3-DPG), decreasing hemoglobin-oxygen (HbO) affinity to improve oxygen offloading and promote hemoglobin polymerization (sickling) of red blood cells (RBCs). We report the discovery of FT-4202, an investigational, selective pyruvate kinase type-R (PKR) activator with a multimodal mechanism of action and potential to increase ATP and decrease 2,3-DPG, resulting in increased HbO affinity, decreased Hb polymerization, and improved RBC health. FT-4202 was identified via structure-enabled lead optimization medicinal chemistry using X-ray crystallography, molecular modeling, and thermal shift assays.
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