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A 3D Computational Study on the Formation and Progression of Tumor Cells in Diffuse Gastric Cancer.
Bull Math Biol
January 2025
CFisUC, Department of Physics, University of Coimbra, Rua Larga, 3004-516, Coimbra, Portugal.
Hereditary diffuse gastric cancer is characterized by an increased risk of diffuse gastric cancer and lobular breast cancer, and is caused by pathogenic germline variants of E-cadherin and -E-catenin, which are key regulators of cell-cell adhesion. However, how the loss of cell-cell adhesion promotes cell dissemination remains to be fully understood. Therefore, a three-dimensional computer model was developed to describe the initial steps of diffuse gastric cancer development.
View Article and Find Full Text PDFSurgical excision of symptomatic lateral band snapping syndrome in small finger proximal interphalangeal joint.
BMJ Case Rep
January 2025
Orthopedic Surgery, OhioHealth, Columbus, Ohio, USA.
Lateral band snapping syndrome can be a debilitating condition involving the proximal interphalangeal (PIP) joint of the fingers. Although rare, it is thought to occur due to disruption of the finger extensor mechanism allowing inappropriate subluxation of the lateral bands over the PIP joint, leading to mechanical and painful symptoms.Here, we describe a woman in her early 40s with a painful, snapping PIP joint secondary to a work-related injury.
View Article and Find Full Text PDFCell shape modulates mitotic spindle positioning forces via intracellular hydrodynamics.
Curr Biol
December 2024
Université Paris Cité, CNRS, Institut Jacques Monod, 75013 Paris, France; Equipe Labellisée LIGUE Contre le Cancer, 75013 Paris, France. Electronic address:
The regulation of mitotic spindle positioning and orientation is central to the morphogenesis of developing embryos and tissues. In many multicellular contexts, cell geometry has been shown to have a major influence on spindle positioning, with spindles that commonly align along the longest cell shape axis. To date, however, we still lack an understanding of how the nature and amplitude of intracellular forces that position, orient, or hold mitotic spindles depend on cell geometry.
View Article and Find Full Text PDFBelieving in organisms: Kant's non-mechanistic philosophy of nature.
Stud Hist Philos Sci
January 2025
Colby College, 4550 Mayflower Hill, Lovejoy 247, Waterville, ME, 04901, USA. Electronic address:
In this paper, I defend a non-mechanistic interpretation of Kant's philosophy of nature. My interpretation contradicts the robust tradition of reading Kant as a mechanist about nature - or as someone who endorses the view that we can know the internally purposive causality characteristic of organisms has no place in nature. By attending closely to Kant's remarks about the possibility of internal purposiveness in nature and to key premises from Kant's arguments in the Antinomy of Teleological Judgment, we shall see that it is not only plausible, but preferable, to believe that internally purposive things (i.
View Article and Find Full Text PDFEffects of Ab501 (certolizumab mice equivalent) in arthritis induced bone loss.
ARP Rheumatol
January 2024
Instituto de Medicina Molecular-João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Portugal.
Introduction - Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease, which causes local and systemic bone damage. The main goal of this work was to analyze, how treatment intervention with Ab501 (certolizumab mice equivalent) prevents the disturbances on bone structure and mechanics induced by arthritis. Methods - Thirty DBA/1 collagen-induced arthritis (CIA) mice were randomly housed in experimental groups, as follows: arthritic untreated (N=9), preventive intervention (N=10) and treatment intervention (N=11).
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