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Diagnostic Value of Cerebrospinal Fluid Sequencing for Neurosyphilis with Cognitive Impairment.
Biomed Environ Sci
November 2024
Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, China.
Neurosyphilis (NS) is an infectious disease caused by invading the central nervous system. It can manifest at any stage of syphilis, and is often misdiagnosed due to its atypical and progressive symptoms. The increasing incidence of NS underscores the necessity for early and accurate diagnosis.
View Article and Find Full Text PDF[Diagnostic, Therapeutic and Monitoring Approach in Suspected Neurosyphilis: Proposal for a Clinical Guideline].
Acta Med Port
December 2024
Serviço de Doenças Infeciosas. Unidade Local de Saúde de São João. Porto; Departamento de Medicina. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
This clinical guideline was designed to serve as a hospital guide in the diagnostic, therapeutic, and monitoring approach to neurosyphilis, considering whether there is positivity or not for the human immunodeficiency virus. Syphilis is a sexually transmitted notifiable disease, known as the great imitator. In around 30% of cases of untreated disease, there is a persistent central nervous system infection.
View Article and Find Full Text PDFA congenital syphilitic child to an adequately treated syphilitic mother.
Indian J Sex Transm Dis AIDS
February 2021
Department of STD, Madurai Medical College, Government Rajaji Hospital, Madurai, Tamil Nadu, India.
A mentally ill antenatal mother of 34 weeks gestation was diagnosed as a case of latent syphilis of unknown duration and was treated adequately with benzathine penicillin. One month after last dose of penicillin she delivered a male baby without any clinical or radiological evidence of syphilis, but reactive RPR in 1:64 dilution. Baby was treated as per CDC guidelines.
View Article and Find Full Text PDFUgo Cerletti (1877-1963): An Early Italian Father of Electroshock and a Pioneer in Many Other Ways.
Neuroscientist
October 2021
Office for the Study of History of Hellenic Naval Medicine, Naval Hospital of Athens, Athens, Attiki, Greece.
This article provides a biographical review of the life and the professional achievements of the Italian doctor Ugo Cerletti and an introduction on electroshock. Throughout his medical career, he travelled and studied in many countries all over the world. Building upon his systematic and comprehensive analysis of mental diseases, Cerletti introduced electroshock, which, at his time, was a novel therapeutic method.
View Article and Find Full Text PDFMultiple intracranial and spinal cord syphilitic gummas in a human immunodeficiency virus-negative man with untreated syphilis: A case report.
Medicine (Baltimore)
September 2019
Department of Neurology, the Third Hospital of Mianyang.
Rationale: Multiple syphilitic gummas involving both the brain and spinal cord are quite rare. Central nervous system (CNS) syphilitic gummas are commonly misdiagnosed as CNS tumors, and clinical suspicion and diagnosis of a syphilitic gumma by physicians are vital to avoiding unnecessary surgeries. Our case emphasizes the importance of routine serologic syphilis tests and standard therapy with penicillin in patients with a CNS mass.
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