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Annals Graphic Medicine - 2 Face Comics Presents: Art Is the Best Medicine.
Ann Intern Med
January 2025
Brown University, Providence, Rhode Island (R.A.).
A quasi affine transformation evolution algorithm with evolution matrix selection operation for parameter estimation of proton exchange membrane fuel cells.
Sci Rep
January 2025
Computer Science Department, Al Al-Bayt University, Mafraq, 25113, Jordan.
Electrochemical energy conversion technologies include proton exchange membrane fuel cells (PEMFCs) where proton interchange is an alternative to diesel distributed generation, and PEMFCs are considered as a promising backup power source and a tool to regulate power consumption. Some of the major benefits of these PEMFCs especially in power system applications include low emission of carbon, fast load following capability, no noise and high start-up reliability. It is challenging to find the best PEMFC parameters because the model is complex and the problem is nonlinear; not all optimization algorithms can solve this problem.
View Article and Find Full Text PDFPrecision fermentation in the realm of microbial protein production: State-of-the-art and future insights.
Food Res Int
January 2025
Renewable Carbon and Biology System (ReCABS) Laboratory, Department of Biotechnology, Engineering School of Lorena, University of São Paulo (EEL-USP), Lorena 12602-810, SP, Brazil. Electronic address:
Food security issues are becoming more pressing due to the world's rapid population expansion and climate change, which also drive up demand for nutrient-dense commodities like meat and cereals. Conventional agricultural practices, which depend on pesticides, fertilizers, and antibiotics, are exacerbating environmental problems, such as antibiotic resistance. Precision fermentation has become a game-changing technique that uses microorganisms to create high-value food ingredients more efficiently and with less negative environmental impact.
View Article and Find Full Text PDFFerroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium.
Free Radic Biol Med
January 2025
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:
Cell death under stress conditions like hypoxia, involves multiple interconnected pathways. In this study, a stable dihydroorotate dehydrogenase (DHODH) knockdown human corneal epithelial cell line was established to explore the regulation of hypoxic cell death, which was mitigated by various cell death inhibitors, particularly by a lipid peroxyl radical scavenger liproxstatin-1 (Lip-1), suggesting that hypoxic cell death involves crosstalk of ferroptosis and PANoptosis. We discovered that both DHODH and Glutathione peroxidase 4 (GPX4) protected cells from hypoxic death by inhibiting lipid peroxidation, mitochondrial reactive oxygen species (ROS) and maintaining mitochondrial membrane potential.
View Article and Find Full Text PDFCausal Discovery with Generalized Linear Models through Peeling Algorithms.
J Mach Learn Res
January 2024
Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA.
This article presents a novel method for causal discovery with generalized structural equation models suited for analyzing diverse types of outcomes, including discrete, continuous, and mixed data. Causal discovery often faces challenges due to unmeasured confounders that hinder the identification of causal relationships. The proposed approach addresses this issue by developing two peeling algorithms (bottom-up and top-down) to ascertain causal relationships and valid instruments.
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