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Background: HIV infection is associated with a significant kidney disease burden. This study is aimed to screen for kidney disease in all HIV patients on highly active anti retroviral therapy (HAART), study clinico-histological correlation, and assess the impact of early diagnosis on the clinical course.

Materials And Methods: It was a prospective, longitudinal study done in a tertiary care hospital.

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Article Synopsis
  • - This case report details an unusual instance of acute kidney injury (AKI) along with nephrotic syndrome in a Pacific Islander who also had acute HIV and hepatitis B virus (HBV) coinfections, ultimately requiring hemodialysis.
  • - The patient fully recovered and ceased dialysis after receiving high-dose steroids and antiviral treatment, with the renal biopsy showing signs of both HIV-associated and HBV-associated nephropathy, as well as significant CD8 lymphocyte infiltration.
  • - The report underscores management challenges, particularly regarding the decision to start antiviral treatment alongside immunosuppressive therapy, and notes that combined nephropathy in HIV-HBV co-infection is extremely rare and has not been previously reported.
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Kidney disease poses a significant burden on individuals with HIV infection. In the pre-ART era, HIV-associated nephropathy (HIVAN) was the most common renal pathology identified in individuals with HIV. However, the widespread use of ART has led to changes in the spectrum of renal pathologies associated with HIV.

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Objectives: HIV-associated kidney disease is common but data on the pathology spectrum of kidney biopsy in China is lacking. This study aimed to illustrate the clinical presentation, laboratory findings and pathological spectrum of different subtypes of HIV-associated kidney disease in China.

Methods: Eighteen HIV patients with renal biopsy indications at the Peking Union Medical College Hospital from January 2002 to October 2021 were retrospectively enrolled.

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