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Myopericarditis in a Patient With Cryoglobulinemic Kidney Disease: A Case Report.
Cureus
December 2024
Nephrology, Ibn Sina Hospital, Rabat, Rabat, MAR.
Cryoglobulinemic vasculitis is a rare small-vessel vasculitis leading to multi-organ dysfunction, often associated with chronic infections like hepatitis C virus (HCV), and autoimmune disorders. Most cases involve mixed monoclonal or polyclonal immunoglobulins, presenting symptoms such as purpura, arthralgias, and weakness. Severe organ involvement, particularly cardiac, is rare but potentially life-threatening.
View Article and Find Full Text PDFUnderstanding the relationship between HCV infection and progression of kidney disease.
Front Microbiol
June 2024
Department of General Surgery, Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, China.
Hepatitis C virus (HCV) can cause a range of kidney diseases. HCV is the primary cause of mixed cryoglobulinaemia, which leads to cryoglobulinaemic vasculitis and cryoglobulinaemic glomerulonephritis (GN). Patients with acute cryoglobulinaemic vasculitis often exhibit acute kidney disease due to HCV infection, which typically progresses to acute kidney injury (AKI).
View Article and Find Full Text PDFAn Aggressive Case of Cryoglobulinemia and Membranoproliferative Glomerulonephritis: A Case Report.
Cureus
June 2024
Department of Internal Medicine, Mercy Hospital, Rogers, USA.
Article Synopsis
- - This case report focuses on a 66-year-old woman diagnosed with membranoproliferative glomerulonephritis (MPGN) linked to Hepatitis C and mixed cryoglobulinemia, featuring rare but severe pulmonary issues.
- - The patient experienced multiple hospitalizations within a few weeks due to acute respiratory symptoms and had diagnostic tests reveal significant lung and kidney complications.
- - Despite treatment with steroids and rituximab, the patient's condition worsened, leading to a decision for comfort care, highlighting the complex and challenging nature of managing serious cases of mixed cryoglobulinemia with multi-organ impact.
Article Synopsis
- Mixed cryoglobulinemia is a small vessel vasculitis often linked to hepatitis C, but can also arise from other disorders, including autoimmune conditions, and has rarely been associated with influenza vaccination.
- A 68-year-old male experienced skin rash and swelling after receiving the flu vaccine, leading to the discovery of mixed cryoglobulins in his lab results.
- Following severe symptoms, including kidney issues, he was treated with rituximab and showed significant recovery, highlighting the need for awareness of cryoglobulin production in response to vaccines for better monitoring and treatment.
Cryoglobulinemic vasculitis and acute disseminated encephalomyelitis (ADEM) are characterized by damage to either blood vessels or grey matter. For both diseases, infections can be an etiology. In cryoglobulinemic vasculitis, the initial insult causes damage to the glomerulus, and in the case of ADEM, damage leads to a central nervous system demyelinating disorder.
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