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New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice.
Neurobiol Aging
December 2024
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal; Centro Clínico e Académico de Coimbra, Coimbra, Portugal; Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Coimbra Institute of Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Curcumin has been proposed as a potential treatment for Alzheimer's disease (AD) due to its ability to inhibit amyloid-β (Aβ) peptide aggregates and to destabilise pre-formed ones. Derivative 27 was synthesized to improve low-dose efficacy in the context of AD. Its anti-inflammatory, antioxidant and anti-amyloidogenic activities were evaluated in chemico, in vitro using AD and neuroinflammation cell models, and in vivo using the double-transgenic APP/PS1 mice.
View Article and Find Full Text PDF[Analysis of laboratory tests in adults with diabetes in Hungary].
Orv Hetil
December 2024
1 Semmelweis Egyetem, Egészségügyi Menedzserképző Központ, Betegbiztonsági Tanszék Budapest, Kútvölgyi út 2., 1125 Magyarország.
Biopreservation and reversal of oxidative injury during blood storage by a novel curcumin-based gel formulation.
Sci Rep
December 2024
Laboratory of Biochemistry and Vascular Biology, Center for Biologic Evaluation and Research, Food and Drug Administration, Bethesda, 20993, MD, USA.
Blood storage lesion induces cytosolic and membrane changes driven in part by hemoglobin (Hb) oxidation reactions within red blood cells (RBCs). A novel gel formulation containing the antioxidant curcuminoids in a biocompatible solvent system was used to deliver curcumin into RBCs. Incubation of peroxide treated RBCs stored in PBS with curcumin gel led to a reduction in prooxidant ferrylHb and recovery in ATP.
View Article and Find Full Text PDFThe correlation between hemoglobin concentration and blood pressure during pregnancy in different trimesters.
BMC Pregnancy Childbirth
December 2024
Department of Public Health, Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Background: Maternal hemoglobin (Hb) is related to nutritional status, and it widely fluctuates during pregnancy. However, the relationship between Hb and blood pressure (BP) during pregnancy is unclear. This study aimed to estimate the associations between maternal Hb in various trimesters and its changes with BP during pregnancy.
View Article and Find Full Text PDFDiagnostic value of hemoglobin concentration in identifying Meckel's diverticulum in pediatric lower gastrointestinal bleeding.
Pediatr Surg Int
December 2024
Pediatric Surgery Department, Hospital Universitari i Politècnic La Fe, Av/Fernando Abril Martorell 106, 46026, Valencia, Spain.
Purpose: To assess the diagnostic performance of hemoglobin concentration for Meckel's diverticulum (MD) and evaluate if hemoglobin levels could be useful in the surgical decision-making process of children with lower gastrointestinal bleeding (LGIB).
Methods: Retrospective cohort study of children with LGIB attending the emergency department between 2011 and 2021. Episodes of LGIB were divided into two groups: MeckD (MD diagnosed by surgery) and non-MeckD.
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