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Advances in the Treatment of Congenital Infiltrating Lipomatosis of the Face: The Role of PIK3CA Mutations and Microvascular Reconstruction.
J Craniofac Surg
January 2025
Department of Oral Maxillofacial Surgery, Walter Reed National Military Medical Center.
Congenital infiltrating lipomatosis of the face is a rare aggressive-benign disorder characterized by progressive hemifacial overgrowth and complex, often asymmetrical, facial differences. Recently linked with the PIK3CA-Related Overgrowth Spectrum, it arises from mosaic mutations in the PIK3CA gene. Treatment, largely supportive and tailored to individual clinical presentations, requires a multidisciplinary approach.
View Article and Find Full Text PDFSmart PDOs™ and the Cartesian Technique™: A milestone in facial rejuvenation with bioactive scaffolds.
J Cutan Aesthet Surg
October 2024
Department of Academic Research, Foundation Center for Aesthetic Medicine Studies, Caracas, Venezuela.
Article Synopsis
- The study investigates the effectiveness of Smart PDOs™ sutures for controlled silicon release and the Cartesian Technique™ for face lifting.
- It involved both preclinical testing (using microscopy and spectroscopy) and clinical trials with 35 patients, focusing on improvements in skin turgidity and wrinkle reduction after treatment.
- Results showed significant improvements in skin appearance and collagen quality, indicating that combining Smart PDOs™ with the Cartesian Technique™ is an effective method for enhancing skin rejuvenation.
Concurrent PIK3CA and IDH1 variants in facial infiltrating lipomatosis with intracranial lesions.
Genes Dis
March 2025
Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
An immortalized adipose-derived stem cells line from the -related overgrowth spectrum: Unveiling novel therapeutic targets.
Biochem Biophys Rep
December 2024
Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
PIK3CA-related overgrowth spectrum (PROS) encompasses several rare conditions that lead to overgrowth of various body parts resulting from activating variants in . The absence of ideal cell models significantly impedes progress in PROS research. In this study, we focused on facial infiltrating lipomatosis (FIL) (A disorder within PROS) and aimed to establish and characterize an immortalized PROS cell line.
View Article and Find Full Text PDFUnravelling the unique case of congenital infiltrating lipomatosis of face with its rare associations-A case report.
J Oral Biol Craniofac Res
October 2024
Department of ENT, All India Institute of Medical Sciences, Bathinda, Punjab, 151001, India.
Article Synopsis
- Congenital infiltrating lipomatosis of facial (CIL-F) is a rare fat tissue tumor that causes progressive facial deformities affecting bones, muscles, and joints.
- A unique case is presented involving a young patient with CIL-F who also suffered from left-sided temporomandibular joint (TMJ) ankylosis, leading to facial swelling and limited mouth opening.
- The report emphasizes the importance of imaging techniques like CT and MRI in diagnosing CIL-F and discusses its rare associations, including TMJ ankylosis and extraocular muscle hypertrophy.
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