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Evaluation of the decision-making process underlying the initial off-label use of vaccines: A scoping review.
Vaccine
October 2024
Centre de Recherche, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal Faculty of Medicine, Montreal, Quebec, Canada. Electronic address:
Background: This scoping review aimed to assess the non-standardized decision-making process of National or International Immunization Technical Advisory Groups (NITAG) in developing novel off-label recommendations by examining the supportive evidence.
Methods: We used the Joanna Briggs Institute framework. A search strategy was developed with a librarian to identify recommendations and evidence from peer-reviewed and gray literature until January 2022, using PubMed, Medline, EMBASE, clinicaltrials.
The role of topical insulin in ocular surface restoration: A review.
Surv Ophthalmol
September 2024
Department of Ophthalmology, Universitair Ziekenhuis Brussel, Jette, Belgium; Department of Medicine and Pharmacology, Vrije Universiteit Brussel (VUB), Brussels, Belgium; Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium; Department of Medicine, Antwerp University Hospital, Antwerp, Belgium.
Corneal epithelial defects are one of the most common ocular disorders. Restoring corneal integrity is crucial to reduce pain and regain function, but in cases of neurotrophic or desensitized corneas, healing can be significantly delayed. Treating neurotrophic corneas is challenging for ophthalmologists, and surgical intervention is often indicated to manage refractory cases that are unresponsive to medical therapy.
View Article and Find Full Text PDFEvidence-based herbal treatments in liver diseases.
Hepatol Forum
January 2024
Department of Pharmacognosy and Pharmaceutical Botany, Gazi University Faculty of Pharmacy, Ankara, Turkiye.
The liver is the main organ for metabolic and detoxification reactions in the body. Therefore, its diseases can be associated with both metabolic disorders, such as insulin resistance, obesity, diabetes, or dyslipidemia, and exogenous insults such as drugs, xenobiotics, or alcohol. Indeed, lifestyle changes are the primary approaches for the prevention and treatment of liver diseases.
View Article and Find Full Text PDFRituximab use in paediatric nephrology practice in Türkiye: TRTX.
Nephrology (Carlton)
May 2024
Department of Pediatric Nephrology, Gazi University, Ankara, Turkey.
Aim: Rituximab (RTX) is a genetically engineered chimeric monoclonal antibody which binds directly to CD20 antigen and mediates inhibition of B cell development. Although RTX has been widely used in paediatric nephrology, there is no routine protocol for its use. In this study, paediatric nephrologists in Türkiye were asked to fill out a questionnaire to understand their practice in using RTX.
View Article and Find Full Text PDFAre the deprescribing guidelines for proton pump inhibitors in palliative care applicable? A monocentric observational study.
BMJ Support Palliat Care
January 2024
INSERM UMR 1246 SPHERE, Nantes Université, Nantes, France.
Objectives: Proton pump inhibitors (PPIs) are among the most commonly prescribed medications. The aim of this study was to assess the appropriateness of prescribing PPIs in the palliative care unit on admission and during hospitalisation to determine the applicability of deprescribing recommendations.
Methods: A monocentric observational study was conducted over a 6-month period in 2020 in a university palliative care unit.
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