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Development and validation of a prognostic nomogram for predicting of patients with acute sedative-hypnotic overdose admitted to the intensive care unit.

Sci Rep

January 2025

Emergency Medicine Laboratory and the Department of Emergency, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.

To develop and evaluate a predictive model for intensive care unit (ICU) admission among patients with acute sedative-hypnotic overdose. We conducted a retrospective analysis of patients admitted to the emergency department of West China Hospital, Sichuan University, between October 11, 2009, and December 31, 2023. Patients were divided into ICU and non-ICU groups based on admission criteria including the need for blood purification therapy, organ support therapy (ventilatory support, vasoactive drugs, renal replacement therapy, artificial liver), or post-cardiopulmonary resuscitation.

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Sex Differences in Neurological Outcome at 6 and 12 Months Following Severe Traumatic Brain Injury. An Observational Analysis of the OXY-TC Trial.

J Neurotrauma

January 2025

Department of Anaesthesia and Intensive Care, Centre Hospitalier Universitaire Grenoble, and Inserm, U1216, Grenoble Institut Neurosciences, University Grenoble Alpes, Grenoble, France.

The effect of sex in outcomes after severe traumatic brain injury (TBI) remains uncertain. We explored whether outcomes differed between women and men after standardized care management during the first 5 days in the intensive care unit (ICU). This study was an observational analysis of the OXY-TC multicenter randomized clinical trial between June 15, 2016 and April 17, 2021.

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Amanita pantherina poisoning is a rare event poorly described. The clinical picture is usually associated with the one of A. muscaria, but A.

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Article Synopsis
  • Early treatment of elevated intracranial pressure (ICP) in severe traumatic brain injury (TBI) is critical, but managing refractory high ICP is difficult due to limited therapeutic options.
  • Controlled lumbar cerebrospinal fluid (CSF) drainage is an effective ICP reduction method that has not been widely adopted due to safety concerns, despite being used at the authors' center for over 15 years.
  • A study of 45 severe TBI patients showed that lumbar drainage significantly reduced episodes of ICP and the need for further invasive therapies, resulting in improved in-hospital mortality and better functional outcomes six months post-injury.
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A Survey on the Management of Patients with Severe Traumatic Brain Injury During Pregnancy: The MAMA Study.

Neurocrit Care

September 2024

Department of Anesthesia and Intensive Care, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Policlinico San Martino, Genoa, Italy.

Article Synopsis
  • Trauma, particularly traumatic brain injury (TBI), is a significant cause of maternal mortality during pregnancy, yet there is a lack of guidelines for managing these cases.
  • An international survey with 122 physicians from 110 centers revealed that many do not have specific protocols for TBI in pregnant patients and highlighted a preference for using MRI and varying practices regarding transfusions and treatment methods.
  • The findings indicate substantial inconsistency in how severe TBI is managed in pregnant individuals, suggesting a need for more research and education to standardize care.
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