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Unveiling nature's antidiabetic potential in Berberis orthobotrys seeds for alloxan-induced diabetic rats.
Sci Rep
January 2025
Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
To illustrate the anti-diabetic properties of Berberis orthobotrys seeds was the aim of the current study. After a series of experiments, two doses of aqueous methanolic extract of the seeds were selected i.e.
View Article and Find Full Text PDFPentose phosphate pathway of glucose-6-phosphate oxidation in the liver of rats with alloxan diabetes on the background of melatonin administrations and variable photoperiod.
Pol Merkur Lekarski
December 2024
BUKOVYNIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE.
Objective: . Aim: To find out the influence of melatonin on the enzyme activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and transketolase in the liver of rats with alloxan diabetes under conditions of variable photoperiod.
Patients And Methods: Materials and Methods: Experiments were conducted on male outbred white rats weighing 180±10 mg.
Captopril inhibits the overproduction of proopiomelanocortin and adrenocorticotropic hormone in the pituitary gland of male diabetic mice in close relationship with an increase in glucocorticoid receptor expression.
Eur J Pharmacol
December 2024
Laboratório de Inflamação, Centro de Pesquisa, Inovação e Vigilância em COVID-19 e Emergências Sanitárias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, nº 4036, Manguinhos, CEP 21040-361, Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação (INCT-NIM), Brazil. Electronic address:
Prior investigation shows that diabetic patients present hypothalamus-pituitary-adrenal (HPA) axis hyperactivity related to impaired negative feedback. This study investigates the effect of Captopril on the overproduction of adrenocorticotropic hormone (ACTH) and its precursor proopiomelanocortin (POMC) in the pituitary gland of male diabetic mice. Diabetes was induced by intravenous injection of alloxan into fasted Swiss-webster mice, and the animals were treated with Captopril for 14 consecutive days, starting 7 days post-diabetes induction.
View Article and Find Full Text PDFAntidiabetic and Anti-Inflammatory Effect of Oil in Alloxan-Induced Diabetic Rats.
Pharmaceuticals (Basel)
August 2024
Liver Unit, Department of Internal Medicine, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey 64460, Nuevo León, Mexico.
Diabetes mellitus presents a great diversity of treatments that cause adverse effects; therefore, plants are a source of compounds that may have fewer adverse effects; () has compounds with potential antidiabetic activity. The objective was to evaluate the antidiabetic effect of oil (CCO) and its impact on oxidative stress in Wistar rats. Five groups were evaluated: (1) sham (SH), (2) 300 mg/kg CCO (CCO), (3) diabetic (D) induced with alloxan, (4) D + 300 mg/kg of CCO (D + CCO), and (5) D + 500 mg/kg of metformin (D + MET); all were treated for 5 days.
View Article and Find Full Text PDFEvaluation of the Hypoglycemic and Hypolipidemic Potential of Extract Fraction of Griff Seeds in Alloxan-induced Diabetic Mice.
Curr Pharm Des
October 2024
Department of Horticulture and Life Science, Yeungnam University, Gyeongsan, Republic of Korea.
Introduction: The discovery and development of new phytomedicines can be greatly aided by plants because of their tremendous therapeutic benefits, efficiency, cost-effectiveness, lack of side effects, and cheaper therapies. In this regard, , generally known as oak, is used in folkloric medicine for treating and preventing various human disorders, including diabetes.
Aim: For this purpose, the present study aimed to evaluate crude methanolic extract and various fractions of for antihyperlipidemic and antihyperglycemic potential followed by the analysis of active compounds.
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