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Kallikrein-Related Peptidase 6 Contributes to Murine Intestinal Tumorigenesis Driven by a Mutant Gene.
Cancers (Basel)
November 2024
Department of Cellular and Molecular Medicine, The University of Arizona Cancer Center, Tucson, AZ 85724-5024, USA.
Article Synopsis
- - The study aimed to evaluate how the serine protease KLK6 affects colorectal cancer development in mice with a mutant tumor suppressor gene, finding that KLK6 expression increases significantly in tumors compared to normal tissue.
- - Techniques like immunohistochemistry confirmed KLK6 presence, and genetically altered mice lacking KLK6 showed smaller tumor sizes and fewer adenomas, indicating KLK6's crucial role in tumor growth.
- - The research highlights KLK6 as an important factor for intestinal tumorigenesis, suggesting it could be useful for early diagnosis of colorectal cancer.
Evaluating Immune Checkpoint Blockade in Metastatic Castration-Resistant Prostate Cancers with Deleterious CDK12 Alterations in the Phase 2 IMPACT Trial.
Clin Cancer Res
August 2024
Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan.
Purpose: CDK12 inactivation in metastatic castration-resistant prostate cancer (mCRPC) may predict immunotherapy responses. This phase 2 trial evaluated the efficacy of immune checkpoint inhibitor (ICI) therapy in patients with CDK12-altered mCRPC.
Patients And Methods: Eligible patients had mCRPC with deleterious CDK12 alterations and any prior therapies except ICI.
Human butyrylcholinesterase in Cohn fraction IV-4 purified in a single chromatography step on Hupresin.
PLoS One
January 2023
Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Protection from the toxicity of nerve agents is achieved by pretreatment with human butyrylcholinesterase (BChE). Current methods for purifying large quantities of BChE from frozen Cohn fraction IV-4 produce 99% pure enzyme, but the yield is low (21%). Our goal was to simplify the purification procedure and increase the yield.
View Article and Find Full Text PDFMolecular features and race-associated outcomes of SPOP-mutant metastatic castration-resistant prostate cancer.
Prostate
May 2023
Department of Internal Medicine, Henry Ford Health System, Henry Ford Cancer Institute, Detroit, Michigan, USA.
Background: Inactivating alterations in SPOP frequently occur in prostate cancer and promote increased dependency on androgen receptor (AR)-mediated oncogenic signaling. The presence of SPOP mutation (SPOP-mutant [SPOP-mut]) may therefore impact therapeutic outcomes with AR-directed therapies and docetaxel in metastatic castration-resistant (mCRPC).
Methods: This was a retrospective study of mCRPC patients treated at an urban academic hospital (n = 103).
Sex-specific Regulation of Prolactin Secretion by Pituitary Bradykinin Receptors.
Endocrinology
September 2022
Laboratorio de Fisio-Patología Hormonal, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina.
Sex differences in the control of prolactin secretion are well documented. Sex-related differences in intrapituitary factors regulating lactotroph function have recently attracted attention. Sex differences in prolactinoma development are well documented in clinic, prolactinomas being more frequent in women but more aggressive in men, for poorly understood reasons.
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