On 132 patients with case history of rhinitis and/or asthma in a domestic environment and with positive cutaneous tests contrasted with D. pteronyssinus, we have made cutaneous tests compared to said antigen and compared with D. farinae, L. destructor and A. siro, with extracts 5000 E/ml (Noon Units), as well as FAST inhibition, using D. pteronyssinus in its solid phase and all the above mentioned extracts in their liquid phase. Our results show that the frequency of D. pteronyssinus positivities in prick is greater than the other mites as well as the intensity of the response expressed in the size of the wheal showing significant differences between those found for D. pteronyssinus and those obtained with other mites. In turn those obtained with the D. farinae are significantly greater than those obtained with non-pyroglyphide mites. In FAST inhibition we only found a good correlation for D. pteronyssinus-D. pteronyssinus and D. pteronyssinus-D. farinae and there is no good correlation between the other mites. The correlation coefficients differ significantly except for those of the pyroglyphides, and the regression equations show a lack of parallelism in the regression lines. Consequently, on the basis of this study, we conclude that there is no crossed reactivity between D. peteronyssinus and non-pyroglyphide mites.
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Avian Pathol
January 2025
Department of Animal Husbandry, Autonomous University of Chapingo, Chapingo, State of Mexico 56230, Mexico.
Ascites syndrome (AS) is a deadly condition in fast-growing chickens, preceded by pulmonary arterial hypertension (PAH), where the angiotensin II type 1 receptor (ATR1) plays a role. We investigated whether allicin (ALLI), a garlic derivative, could (a) interact with broiler ATR1, (b) affect ascites-related traits [haematocrit content (Hct%), blood oxygen saturation (SaO), and the right-to-total ventricular weight ratio (RV:TV)], (c) modify ATR1 expression in the lung, heart, and liver, alongside ascites mortality and growth performance in Ross 308 broilers raised at high altitude and under cold temperatures promoting PAH/AS. Three groups (n = 70 each) were studied: 0-ALLI (untreated), 1-ALLI (allicin 1 mg/kg body weight/daily at 14-27 days of age by oral-oesophageal route), and 2.
View Article and Find Full Text PDFJ Indian Soc Periodontol
December 2024
Department of Periodontics, Thai Moogambigai Dental College and Hospital, Dr. M.G.R. Educational and Research Institute, Chennai, Tamil Nadu, India.
Background: Periodontitis and diabetes are chronic diseases where inflammation plays a central role, with each condition exacerbating the other. Pyroptosis, an inflammatory form of programmed cell death, is implicated in periodontitis and diabetes. The activation of gasdermin D (GSDMD), a key mediator of pyroptosis, promotes cytokine release and perpetuates tissue destruction in both.
View Article and Find Full Text PDFACS Omega
December 2024
State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Co-Construction Collaborative Innovation Center for Chinese Medicine Resources Industrialization by Shaanxi & Education Ministry, Shaanxi University of Chinese Medicine, Xianyang 712083, China.
Due to the lower oxidation potential than natural nucleic acid bases, one-electron oxidation of DNA is usually funneled into the direction of intermediates for oxidized DNA damage like 8-oxo-7,8-dihydroadenine (8-oxoA) leading to a radical cation, which may undergo facile deprotonation. However, compared to the sophisticated studies devoted to natural bases, much less is known about the radical cation degradation behavior of an oxidized DNA base. Inspired by this, a comprehensive theoretical investigation is performed to illuminate the deprotonation of 8-oxoA radical cation (8-oxoA) in both free and encumbered context by calculating the p value and mapping the energy profiles.
View Article and Find Full Text PDFBioorg Med Chem
December 2024
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address:
The purinergic P2X ligand-gated ion channel 7 receptor (P2X7R) plays a critical role in various inflammatory processes and other diseases. Fast determination of compounds P2X7R binding potency and discovery of a promise PET radiotracer for imaging P2X7R require a P2X7R suitable radioligand for radioactive competitive binding assay. Herein, we designed and synthesized thirteen new P2X7R ligands and determined the in vitro binding potency.
View Article and Find Full Text PDFPLoS One
December 2024
Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China.
Obesity is associated with abnormal repolarization manifested by QT interval prolongation, and oxidative stress is an important link between obesity and arrhythmias. However, the underlying electrophysiological and molecular mechanisms remain unclear. The aim of this study is to evaluate the role of obesity in potassium current in ventricular myocytes and the potential mechanism of NADPH oxidase 2 (Nox2).
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