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A step towards non-invasive diagnosis of diabetes mellitus using synthesized MOF-MXene hybrid material with extended gate field-effect transistor integration.
J Mater Chem B
December 2024
Laboratory of Sensors, Energy and Electronic devices (Lab SEED), Department of Physics and Nanotechnology, SRMIST, Kattankulathur 603203, Tamil Nadu, India.
The increasing demand for non-invasive and non-enzymatic glucose sensors is driven by the objective of eliminating the need for blood pricks from the body and enabling enzyme-free detection of glucose for diagnosing diabetes mellitus. To address this need, we synthesized Ni MOF-MXene (Ni) hybrid material through a one-pot synthesis method, which acts as a catalyst to detect salivary glucose using an extended gate field effect transistor (EGFET) method. The resulting sensor exhibits good selectivity towards glucose over common interfering molecules such as sucrose, fructose, maltose, uric acid, and ascorbic acid under physiological conditions in saliva.
View Article and Find Full Text PDFCorrelation of systemic immune inflammation and serum uric acid with gout: based on NHANES.
Clin Rheumatol
December 2024
Department of Endocrinology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, China.
Objectives: This study aimed to explore the relationship of systemic immune inflammation index (SII) and uric acid with gout using NHANES 2017-2018 data.
Method: Data were collected from the 2017-2018 circle of the NHANES database. SII was calculated based on the counts of lymphocytes (LC), neutrophils (NC), and platelets (PC).
Elevated Blood Glucose Can Promote Uric Acid Excretion: A Cross-Sectional Study Involving Urinary Glucose and Urinary Uric Acid in China.
Diabetes Metab Syndr Obes
November 2024
Department of Health Care, qilu Hospital (Qingdao), cheeloo College of Medicine, Shandong University, Qingdao, Shandong, People's Republic of China.
Article Synopsis
- This study investigates the relationship between uric acid and blood glucose levels, focusing on how urinary glucose affects their excretion.
- A total of 2498 hospitalized patients were recruited, with 1416 included in the final analysis, utilizing various statistical methods to evaluate differences based on gender.
- The findings suggest that higher blood glucose levels, especially when glucosuria occurs, lead to increased uric acid excretion and decreased serum uric acid levels, with a stronger correlation observed in women compared to men.
Article Synopsis
- The study investigates the connection between Life Essentials 8 (LE8) cardiovascular health metrics and the risk of metabolic syndrome (MetS) using data from 23,253 adults in the National Health and Nutrition Examination Survey (2005-2018).
- Results show that participants with high LE8 scores (80-100) had significantly lower odds of having MetS (98% reduction) compared to those with low scores (0-49), suggesting a strong inverse relationship.
- The findings indicate that better cardiovascular health may lead to a reduced risk of MetS, with specific biomarkers identified as potential mediators, although the study’s cross-sectional design limits the ability to establish causation.
The prognostic impact of stress hyperglycemia ratio for all-cause mortality in patients with Psoriasis.
Sci Rep
October 2024
Department of Dermatology and Venereology, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Dermatologic Diseases, Xinjiang Key Laboratory of Dermatology Research, Urumqi, 830001, China.
Aims The stress hyperglycemia ratio (SHR) is a valuable biomarker of acute hyperglycemia, significantly correlated with unfavorable prognosis in various conditions. However, its impact on Psoriasis has not been studied. We explored the association between SHR and long-term mortality in psoriasis patients.
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