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Propantheline bromide in the management of hyperhidrosis associated with spinal cord injury.
Ann Pharmacother
May 1995
Department of Pharmacy and Medicine, University of North Carolina AHEC Program, Wilmington 28402, USA.
Objective: To report 2 cases in which oral propantheline reduced the discomfort associated with sweating related to spinal cord injury (SCI), and to review the literature on the management of SCI-related sweating.
Case Summaries: Case 1: A 27-year-old quadriplegic man with an American Spinal Injury Association (ASIA) Frankel class C injury to C5/C6 experienced profuse sweating and requested propantheline. He stated that he had received the medication previously and reported that propantheline 15 mg tid had controlled his sweating.
The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration.
Life Sci
March 1994
Anaquest, Inc., Murray Hill, NJ 07974.
The alpha 2 agonist clonidine has been shown to be anxiolytic in a number of preclinical anxiety models. Interestingly, intravenous infusion of the alpha 2 antagonists idazoxan at 10 mg/kg and rauwolscine at 2.24 mg/kg significantly disinhibited lick-shock conflict responding in rats similar to the alpha 2 agonist clonidine (0.
View Article and Find Full Text PDFNapamezole, an alpha-2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro.
J Pharmacol Exp Ther
August 1990
Department of Pharmacology, Sterling Research Group, Rensselaer, New York.
Napamezole (2-[3,4-dihydro-2-naphthalenyl)methyl]-4,5-dihydro-1H- imidazole-monohydrochloride) is a selective alpha-2 adrenergic receptor antagonist and a monoamine re-uptake inhibitor in vitro. The alpha adrenergic antagonist activity of napamezole was determined in vitro in rat brain receptor binding assay using [3H]clonidine and [3H]prazosin for alpha-2 and alpha-1 receptors, respectively. The Ki values for napamezole were 28 nM (alpha-2) and 93 nM (alpha-1).
View Article and Find Full Text PDFEffect of catecholaminergic drugs on quinolinate- and kynurenine-induced seizures in mice.
J Neural Transm Gen Sect
November 1990
Laboratory of Psychopharmacology, Bekhterev Psychoneurological Research Institute, Leningrad, USSR.
Administration of reserpine, trifluperidol, chlorpromazine, haloperidol, spiroperidol, and thioproperazine to adult mice shortened the latency and increased the number of animals with clonic seizures induced by 1-kynurenine sulfate or its metabolite quinolinic acid. Haloperidol dose-dependently intensified kynurenine-induced seizures and did not alter pentylenetetrazole seizures. Dopamine abolished the effect of haloperidol while serotonin was ineffective.
View Article and Find Full Text PDFModulation of retinal aromatic L-amino acid decarboxylase via alpha 2 adrenoceptors.
J Neurochem
February 1989
Department of Pharmacology, Ohio State University College of Medicine, Columbus 43210-1239.
Aromatic L-amino acid decarboxylase (AAAD) activity of the rat retina increases when animals are placed in a lighted environment from the dark. The rise of activity can be inhibited by administering alpha 2 adrenoceptor agonists. In the dark, the enzyme activity can be made to increase by administering alpha 2 adrenoceptor antagonist drugs.
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