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User-friendliness of the pain assessment in impaired cognition (PAIC15) in persons with aphasia: a pilot study.
Future Sci OA
December 2025
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.
Background: Persons with aphasia have difficulties communicating pain symptoms.
Methods: Thirteen observers performed multiple observations using the Pain Assessment in Impaired Cognition (PAIC15) scale for persons with aphasia during rest and transfer in persons with aphasia. This pilot study examined the user-friendliness of PAIC15 and preference for type of self-report pain scales with a questionnaire.
Investigating the Impact of B Cell-Related Genes on Colorectal Cancer Immunosuppressive Environment and Immunotherapy Evasion.
Drug Dev Res
February 2025
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
We aimed to elucidate the prognostic and immunological roles of B cell-related genes in colorectal cancer (CRC). This study comprehensively integrated data from single-cell RNA-sequencing, TCGA, GEO, IMvigor210, GDSC, CancerSEA, HPA, and TISIDB databases to explore prognostic implications and immunological significance of B cell-related gene signature in CRC. We identified seven prognostically significant B cell-related genes for constructing a risk score.
View Article and Find Full Text PDFStudy protocol for a randomized control trial investigating the effectiveness of a multifaceted mHealth approach on adherence to antihypertensive treatment among patients in Pakistan.
Pak J Med Sci
January 2025
Dr. Ayesha Babar Kawish, MSPH Al-Shifa School of Public Health, Al-Shifa Trust, Rawalpindi, Pakistan.
Background & Objectives: Poor medication adherence is an essential contributor to Pakistan's high prevalence of uncontrolled hypertension. This study will be aimed to assess the efficacy of a one-of-a-kind developed intervention in improving medication adherence and treatment outcomes in hypertension patients.
Methods: Twleve months duration long randomized controlled trial from January to December 2021 will be carried out at Shaikh Zayed Medical Complex (SZMC), Lahore.
In silico approaches for developing sesquiterpene derivatives as antagonists of human nicotinic acetylcholine receptors (nAChRs) for nicotine addiction treatment.
Curr Res Struct Biol
June 2025
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jalan Raya Bandung-Sumedang KM 21, Sumedang, 45363, Indonesia.
Cinnamomum, a genus within the Lauraceae family, has gained global recognition due to its wide-ranging utility. Extensive research has been dedicated to exploring its phytochemical composition and pharmacological effects. Notably, the uniqueness of Cinnamomum lies in its terpenoid content, characterized by distinctive structures and significant biological implications.
View Article and Find Full Text PDFAttitudes and Behaviors Toward Cardiopulmonary Resuscitation Among Healthcare and Non-healthcare Workers in Japan: A Cross-Sectional Study Using a Web-Based Questionnaire.
Cureus
December 2024
Department of Health and Welfare Services, National Institute of Public Health, Wako, JPN.
Background Cardiopulmonary arrest is a leading cause of death and requires swift intervention for survival. Previous studies have highlighted the critical importance of initiating cardiopulmonary resuscitation (CPR) and defibrillation within a limited timeframe. Improving outcomes depends on widespread CPR training, accessible automated external defibrillators (AEDs), and increased public awareness.
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