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Documentation of International Staging System (ISS) and Revised International Staging System (R-ISS) for Multiple Myeloma at a Tertiary Care Center: A Clinical Audit.
Indian J Clin Biochem
January 2025
Department of Clinical Hematology, Amrita Institute of Medical Sciences, Kochi, Kerala India.
Multiple myeloma (MM) is a highly heterogeneous disease characterised by neoplastic clonal plasma cell proliferation and a wide range of clinical manifestations including skeletal destruction, hypercalcemia, anaemia, renal failure, and immune suppression. Currently accepted and widely used staging criteria for MM patients are the International staging system (ISS) and the Revised International staging system (R-ISS). In order to anticipate outcomes for these patients and to select a risk-adapted therapy, a staging approach that can classify MM patients based on risk at the time of diagnosis itself may be helpful.
View Article and Find Full Text PDFAnti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report.
BMC Neurol
January 2025
Neurology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China.
Background: Autoimmune encephalitis associated with anti-GluK2 antibodies is a recently identified condition, typically characterized by cerebellar ataxia. This case report presents a unique clinical manifestation involving involuntary movements and emotional dysregulation, expanding the known phenotype spectrum.
Case Presentation: A 60-year-old woman presented with a two-year history of involuntary movements predominantly affecting her lower limbs and facial muscles, occasionally accompanied by hysterical shouting.
Updates on mechanisms of disease progression in precursor myeloma: Monoclonal gammopathy of undermined significance and smoldering myeloma.
Presse Med
January 2025
Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are premalignant stages in the development of multiple myeloma (MM). Advances in detection, risk stratification, and therapeutic intervention have transformed our understanding of disease progression. Sensitive techniques like mass spectrometry have identified smaller monoclonal gammopathies, such as monoclonal gammopathy of indeterminate potential (MGIP), which may precede MGUS.
View Article and Find Full Text PDFExtramedullary plasmacytoma is rare, it can appear alone or associated with multiple myeloma, representing an extramedullary progression of the disease. We present the case of a 62-year-old woman diagnosed with multiple myeloma who, being in complete remission began to experience abdominal pain and nausea. A rare cause of intestinal subocclusion and upper gastrointestinal bleeding.
View Article and Find Full Text PDFA Retrospective Analysis of Morbidity and Risk Factors of Multiple Myeloma with Peripheral Neuropathy.
Br J Hosp Med (Lond)
December 2024
Department of Hematology, Hebei General Hospital, Shijiazhuang, Hebei, China.
Peripheral nerve injury affects some people with multiple myeloma; this condition can be brought on by the disease itself or by the treatments they receive. Such a complication increases patients' financial burden, causes treatment to be interrupted or delayed, and reduces treatment efficacy. However, opinions regarding the risk factors for peripheral neuropathy are currently divided.
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