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http://dx.doi.org/10.3181/00379727-76-18640 | DOI Listing |
Talanta
August 2024
Institute of Nutritional Science, Chair of Food Science, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany; Center for Sustainable Food Systems, Justus Liebig University Giessen, Senckenbergstr. 3, 35390, Giessen, Germany. Electronic address:
To analyze a complex sample for endocrine activity, different tests must be performed to clarify androgen/estrogen agonism, antagonism, cytotoxicity, anti-cytotoxicity, and corresponding false-positive reactions. This means a large amount of work. Therefore, a six-fold planar multiplex bioassay concept was developed to evaluate up to the mentioned six endpoints or mechanisms simultaneously in the same sample analysis.
View Article and Find Full Text PDFArch Environ Contam Toxicol
August 2018
Department of Obstetrics, Gynecology and Women's Health, University of Missouri, M659 Medical Sciences Building, 1 Hospital Drive, Columbia, MO, 65211, USA.
Unconventional oil and natural gas (UOG) operations couple horizontal drilling with hydraulic fracturing to access previously inaccessible fossil fuel deposits. Hydraulic fracturing, a common form of stimulation, involves the high-pressure injection of water, chemicals, and sand to fracture the target layer and release trapped natural gas and/or oil. Spills and/or discharges of wastewater have been shown to impact surface, ground, and drinking water.
View Article and Find Full Text PDFSci Total Environ
July 2016
Department of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO 65211, USA. Electronic address:
Currently, >95% of end disposal of hydraulic fracturing wastewater from unconventional oil and gas operations in the US occurs via injection wells. Key data gaps exist in understanding the potential impact of underground injection on surface water quality and environmental health. The goal of this study was to assess endocrine disrupting activity in surface water at a West Virginia injection well disposal site.
View Article and Find Full Text PDFBirth Defects Res B Dev Reprod Toxicol
April 2015
CalEPA's Office of Environmental Health Hazard Assessment (OEHHA), Sacramento, California.
Introduction: The U.S. Environmental Protection Agency's (EPA's) Toxicity Forecaster (ToxCast) is a potential tool for chemical prioritization, hazard identification, and risk assessment.
View Article and Find Full Text PDFReprod Toxicol
August 2015
BioDetection Systems BV, Amsterdam, The Netherlands.
There is a great need for alternative testing methods for reproductive toxicants that are practical, fast, cost-effective and easy to interpret. Previously we followed a pragmatic approach using readily available tests, which was successful in predicting reproductive toxicity of chemicals [13]. This initial battery still contained apical tests and is fairly complex and low in its throughput.
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