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Article Synopsis
  • The study aimed to compare the effectiveness of two sedation combinations—midazolam/meperidine (M/M) vs. midazolam/hydromorphone (M/H)—for pediatric dental patients.
  • A review of charts from healthy children aged 2 to 5 who underwent sedation treatment revealed no significant differences in treatment completion, sedation level, or overall effectiveness between the two groups.
  • However, the M/H group showed better behavioral scores, suggesting that midazolam and hydromorphone could be a preferable option for moderate sedation in these patients.
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There is conflicting evidence regarding the association between epidural labour analgesia and risk of postpartum depression. Most previous studies were observational trials with limited ability to account for confounders. We aimed to determine if epidural analgesia was associated with a significant change in the incidence of postpartum depression in this randomised controlled trial.

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Effects of an intravenous lidocaine bolus before tracheal extubation on recovery after breast surgery - Lidocaine at the End (LATE) study: a randomized controlled clinical trial.

Croat Med J

August 2023

Boris Mraovic, Department of Anesthesiology and Perioperative Medicine, University of Missouri - Columbia, One Hospital Drive DC005.00, Columbia, MO 65212, USA,

Aim: To investigate whether IV lidocaine improves emergence, early recovery, and late recovery after general anesthesia in women who undergo breast surgery.

Methods: Sixty-seven women with American Society of Anesthesiologists physical status I-II, scheduled for breast surgery were randomized to receive an IV lidocaine 1.5 mg/kg bolus (n=34) or saline placebo (n=33) before tracheal extubation.

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Objectives: The objective of this study was to synthesize indication-based evidence for NO for distress and pain in children.

Study Design: We included trials of NO in participants 0-21 years, reporting distress or pain for emergency department procedures. The primary outcome was procedural distress.

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Pharmacologic and nonpharmacologic options for pain relief during labor: an expert review.

Am J Obstet Gynecol

May 2023

Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel; Department of Obstetrics and Gynecology, Holy Family Hospital, Nazareth, Israel. Electronic address:

Labor pain is among the most severe types of physical pain that women may experience during their lifetime. Thus, pain relief is an essential part of medical care during childbirth. Epidural analgesia is considered to be the most efficient method of pain relief during labor.

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