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The genotoxicity of 2,4,6-trinitrotoluene (2,4,6-TNT) and its amino derivative, 2,4-diamino-6-nitrotoluene (2,4-DA-6-NT), was studied using the Escherichia coli tester strain PQ37 in the SOS chromotest. The compound 2,4,6-TNT, without metabolic activation, virtually failed to induce an SOS effect in cells of the tester bacteria. Consequently, mutagenic activity of 2,4,6-TNT, which was shown earlier in the Ames test, does not depend on SOS mutagenesis.
View Article and Find Full Text PDFA study is presented of morbidity with temporary loss of working capacity in mine workers of ore-mining enterprises contacting with trinitrotoluol. Three-year data were analyzed according to an international statistical classification (average 100 workers annually). The frequency of lesions of the skin and subcutaneous fat was higher in workers contacting with trinitrotoluol.
View Article and Find Full Text PDF[Changes in the estrus cycle in experimental animals under the effect of trinitrotoluol].
Akush Ginekol (Sofiia)
December 1973
[Liver steatosis in a subject working for several years with trinitrotoluol].
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove
July 1970
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