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Genetic validation of a TSC2 immunohistochemistry assay in TSC/mTOR-pathway altered renal tumors.
Hum Pathol
November 2024
Department of Pathology, Johns Hopkins School of Medicine, USA; Department of Urology, Johns Hopkins School of Medicine, USA; Department of Oncology, Johns Hopkins School of Medicine, USA. Electronic address:
Article Synopsis
- Pathogenic mutations in genes associated with tuberous sclerosis complex (TSC) affect various types of kidney tumors like eosinophilic solid and cystic renal cell carcinoma (ESC RCC) and oncocytic tumors.
- A study validated a TSC2 immunohistochemistry (IHC) assay on tissues from renal tumors to assess the presence of TSC2 mutations, achieving high predictive values for diagnosing these tumors.
- The findings highlight that TSC2 IHC can help identify renal tumors linked to TSC/mTOR pathway mutations, supporting its use in diagnostic processes.
Comprehensive study of ancient schwannoma: Exploring histomorphological diversity and diagnostic challenges.
Rare Tumors
September 2024
Department of Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, India.
Article Synopsis
- * A study analyzed 248 schwannoma cases over six years, with 25 identified as ancient schwannoma, evaluating their histological features through light microscopy.
- * The findings revealed significant features like nuclear atypia and cystic changes in tumors from various locations, highlighting the need for careful histomorphological assessment to correctly diagnose and manage these tumors.
Xanthogranulomatous pyelonephritis in a patient with polycystic kidney disease without underlying risk factors: a case report.
Front Med (Lausanne)
August 2024
Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.
Xanthogranulomatous pyelonephritis (XGP) is an extremely rare, chronic granulomatous inflammatory condition thought to arise secondary to a combination of obstruction, recurrent bacterial infection and an incomplete immune response although the etiology of XGP is more complex. We would like to report a case of XGP occurring in a patient with polycystic kidney disease (PCKD), which has not been previously documented in etiology. A 29-year-old woman presented to our hospital with right upper quadrant pain for 5 days.
View Article and Find Full Text PDFHistological evidence of MAPK pathway activation across subtypes of adult orbital xanthogranulomatous disease irrespective of the detection of oncogenic mutations.
Clin Immunol
August 2024
The Rotterdam Eye Hospital, Rotterdam, the Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pathology, section Ophthalmic Pathology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address:
Adult orbital xanthogranulomatous disease (AOXGD) is a spectrum of histiocytoses with four subtypes. Mitogen-activated protein kinase (MAPK) pathway mutations have been detected in various histiocytic neoplasms, little is known about this in AOXGD. Targeted regions of cancer- and histiocytosis-related genes were analyzed and immunohistochemical staining of phosphorylated ERK (pERK), cyclin D1 and PU.
View Article and Find Full Text PDFXanthomatous salpingo-oophoritis accompanied by hobnail cell and apocrine metaplasia: The first case report in the literature.
Int J Surg Case Rep
August 2024
Department of Pathology, Cancer Research Center, Tishreen University Hospital, Lattakia, Syria. Electronic address:
Introduction And Importance: Xanthomatous inflammation is a rare chronic inflammatory condition typically affecting organs such as the kidney and gallbladder. Its occurrence in the female genital tract, particularly in the ovaries and fallopian tubes, is exceptionally rare and sparsely documented.
Case Presentation: We report a unique case of xanthomatous inflammation involving the fallopian tube and ovary, characterized by the presence of hobnail cells and apocrine metaplasia.
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