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Quercetin Enhances 5-Fluorouracil-Driven Cytotoxicity Dose-Dependently in A375 Human Melanoma Cells.
Life (Basel)
December 2024
Centre for Translational Research and Systems Medicine, "Victor Babeș" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Cutaneous melanoma (CM) represents a severe skin cancer with a rising incidence at present and limited treatment options. 5-Fluorouracil (5-FU) is widely used, including for CM; however, the innate resistance of this cancer to conventional therapy remains problematic. Quercetin (QUE) is a flavonoid that can sensitize cancer cells to antitumor agents such as 5-FU.
View Article and Find Full Text PDFPainful knee prosthesis: surgical approach.
Clin Cases Miner Bone Metab
May 2011
First Orthopaedic Clinic, University of Florence, Florence, Italy.
There are many conditions that may be responsible of a painful knee prosthesis. The possible causes are not always easily diagnosed. Common causes of prosthetic failure, such as aseptic loosening, infection, instability, progressive patellar arthropathy and recurrent synovitis are associated with clearly defined radiographic and/or clinical evidence.
View Article and Find Full Text PDF[The immune system of the skin and stereotyped reaction patterns in inflammatory skin diseases].
Ned Tijdschr Geneeskd
April 2006
VU Medisch Centrum, afd. Pathologie, Postbus 7057, 1007 MB Amsterdam.
The clinical and histological presentation of inflammatory disease in the skin is exceedingly heterogeneous. Nonetheless, most inflammatory dermatoses can be classified according to five stereotypical tissue-reaction patterns: the spongiotic, the lichenoid, the psoriasiform, the vesiculo-bullous and the vasculopathic. By means of potent antigen-presenting cells, cytokine and chemokine cascades and a skin-specific cutaneous lymphocyte antigen (CLA)-positive lymphocyte population, the skin is able to respond very efficiently to pathogens that threaten the individual.
View Article and Find Full Text PDF[Prevalence of seropositividad to antibodies IgG and IgM against Helicobacter pylori in the medical residents of the University Hospital of Puebla].
Rev Alerg Mex
September 2006
Servicio de alergia e inmunología clínica, Hospital Universitario de Puebla, México.
Background: Helicobacter pylori is a gram-negative, curved, microaerophilic, oxidase, catalase and urease positive bacillus. It lives in the gastric mucosa, and is the main etiological agent of peptic ulcer, and of atrophic and multifocal gastritis. It is associated with extraintestinal, vascular, autoimmune and cutaneous diseases.
View Article and Find Full Text PDF[Contact vasculitis caused by topical agents with non-steroidal anti-inflammatory agents or analgesics].
Ann Dermatol Venereol
September 1998
Clinique Dermatologique, Hôpital Charles Nicolle, Rouen.
Introduction: Topical non steroidal antiinflammatory drugs (NSAID) are recently used in France. Seven cases of contact vasculitis due to topical NSAID are reported.
Patients And Methods: The clinical and histological features and follow-up data of seven patients with contact vasculitis due to topical NSAID were retrospectively reviewed.
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