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Investigating Microperimetric Features in Bietti Crystalline Dystrophy Patients: A Cross-Sectional Longitudinal Study in a Large Cohort.
Invest Ophthalmol Vis Sci
November 2024
Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Purpose: To assess the clinical and genetic characteristics of patients with Bietti crystalline dystrophy (BCD) with a focus on potential of microperimetry in monitoring macular function.
Methods: A total of 208 genetically-confirmed BCD patients were enrolled in this retrospective study. The patients were categorized into subgroups based on their fundus characteristics (fovea sparing and fovea involved), optical coherence tomography (OCT) findings (presence/absence of retinal pigment epithelium [RPE] or ellipsoid zone [EZ] line at the fovea/parafovea), and genetic profiles (Mis/Mis, Tru/Mis, Tru/Tru).
A multimodal imaging approach to investigate retinal oxygen and vascular dynamics, and neural dysfunction in bietti crystalline dystrophy.
Microvasc Res
January 2025
Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology&Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Electronic address:
Background: This study aimed to explore retinal changes in Bietti crystalline dystrophy (BCD) patients, including retinal metabolism, blood flow, vascular remodeling, and pupillary light reflex (PLR) abnormalities.
Methods: This cross-sectional study included 120 eyes from BCD patients and 120 eyes from healthy controls, utilizing a multimodal imaging system (MEFIAS 3200, SYSEYE, Chongqing, China) to evaluate retinal oxygenation, blood flow, vascular structure, and PLR. Measurements included oxygen saturation, blood flow velocity, vessel diameters, and pulsatility metrics.
[Multimodal imaging of Bietti's crystalline dystrophy].
J Fr Ophtalmol
October 2024
Service d'ophtalmologie, centre hospitalier Hassan II, hôpital Omar-Drissi, Fès, Maroc; Faculté de médecine et de pharmacie et de médecine dentaire de Fès, université Sidi-Mohammed-Ben-Abdellah, Fès, Maroc.
Prevalence of Certain Corneal Conditions and their Demographic Risk Factors; Tehran Geriatric Eye Study.
Arch Iran Med
August 2024
Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- The study investigated the prevalence of corneal abnormalities among elderly individuals in Tehran, revealing that nearly 50% have some form of such issues, primarily corneal degeneration.
- A total of six types of corneal abnormalities were assessed, with punctate epithelial defect being the second most common at 8.77%.
- The results suggest that older age significantly correlates with corneal abnormalities, and illiteracy was linked to a higher occurrence of posterior embryotoxon.
Quickly diagnosing Bietti crystalline dystrophy with deep learning.
iScience
September 2024
Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Bietti crystalline dystrophy (BCD) is an autosomal recessive inherited retinal disease (IRD) and its early precise diagnosis is much challenging. This study aims to diagnose BCD and classify the clinical stage based on ultra-wide-field (UWF) color fundus photographs (CFPs) via deep learning (DL). All CFPs were labeled as BCD, retinitis pigmentosa (RP) or normal, and the BCD patients were further divided into three stages.
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