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Associations of serum glucocorticoid levels on hypertension and blood pressure-related indicators: a nested case-control study in rural China.
J Hypertens
September 2024
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan.
Background: The relationship between glucocorticoids and hypertension has shown inconsistent findings in previous studies. To address this, our study employed a nested case-control design in rural areas to further investigate the association between serum glucocorticoid levels and hypertension, and blood pressure-related indicators.
Methods: This study employed a nested case-control design, involving 560 pairs of hypertensive cases and matched controls.
ACTH and prolactin synergistically and selectively regulate CYP17 expression and adrenal androgen production in human foetal adrenal organ cultures.
Eur J Endocrinol
September 2023
Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, 06560 Valbonne, France.
Objective: The essential role of ACTH on the growth and function of the human foetal adrenal (HFA) has long been recognized. In addition, many studies have suggested a role of the pituitary hormone prolactin (PRL) in the regulation of the HFA, but the effects of this hormone on steroidogenesis and gene expression are still unknown. Our objective was to investigate the effect of ACTH and PRL on the steroidogenic capacities of the HFA.
View Article and Find Full Text PDFSerum cortisol-to-cortisone ratio and 11-deoxycortisol are associated with hypertension and blood pressure in Chinese rural population: a cross sectional study.
J Hypertens
March 2022
Department of Occupational and Environmental Health.
Objective: The present study aimed to investigate the associations of cortisol-to-cortisone ratio (F/E) and 11-deoxycortisol (S) in hypertension and blood pressure among Chinese rural population.
Methods: A total of 6233 participants from the Henan Rural Cohort Study were included. Serum cortisol (F), cortisone (E), and S were assessed using liquid chromatography-tandem mass spectrometry.
Mucosal Bacteria Modulate Candida albicans Virulence in Oropharyngeal Candidiasis.
mBio
August 2021
Department of Oral Health and Diagnostic Sciences, UConn Health, Farmington, Connecticut, USA.
Oropharyngeal candidiasis (OPC) is the most prevalent oral infection in immunocompromised patients, primarily associated with Candida albicans. Increasing evidence points to a significant role of mucosal bacteria on the transition of C. albicans from commensal to pathogenic.
View Article and Find Full Text PDFDevelopment and validation of an LC-MS/MS assay for the quantification of allopregnanolone and its progesterone-derived isomers, precursors, and cortisol/cortisone in pregnancy.
Anal Bioanal Chem
September 2021
iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Bioscience 2, Suite 200, 12705 East Montview Blvd, Aurora, CO, 80045, USA.
Neuroactive steroids are potent neuromodulators that play a critical role in both maternal and fetal health during pregnancy. These stress-responsive compounds are reportedly low in women with perinatal depression and may be associated with poor pregnancy outcomes in animal models. Chronic stress is a risk factor for adverse birth outcomes.
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