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Hexestrol, an estrogen receptor agonist, inhibits Lassa virus entry.
J Virol
July 2024
Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Article Synopsis
- Lassa virus (LASV) causes severe Lassa fever, resulting in thousands of deaths annually, and currently, there are no approved vaccines or antiviral treatments available.
- Researchers screened around 2,500 compounds and identified hexestrol (HES), an estrogen receptor agonist, as a potential LASV entry inhibitor, showing strong antiviral activity against both recombinant and authentic LASV strains.
- HES works by blocking the membrane fusion step critical for LASV entry, and modifications to the Lassa glycoprotein suggested that the transmembrane region could be an important target for developing new anti-LASV drugs.
Biophysical chemistry behind sickle cell anemia and the mechanism of voxelotor action.
Sci Rep
January 2024
Department of Chemistry, Siddhartha (PG) College, Aakhlor Kheri, Deoband (Saharanpur), Uttar Pradesh, 247554, India.
Sickle cell anemia disease has been a great challenge to the world in the present situation. It occurs only due to the polymerization of sickle hemoglobin (HbS) having Pro-Val-Glu typed mutation, while the polymerization does not occur in normal hemoglobin (HbA) having Pro-Glu-Glu peptides. It is also well confirmed that the oxygenated HbS (OHbS) does not participate in the polymerization, while the deoxygenated HbS (dHbS) does, which causes the shape of red blood cells sickled.
View Article and Find Full Text PDFAntibacterial and antibiofilm efficacy of repurposing drug hexestrol against methicillin-resistant Staphylococcus aureus.
Int J Med Microbiol
March 2023
Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha 410005, Hunan, China. Electronic address:
There has been an explosion in the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) because of the indiscriminate use of antibiotics. In this study, we repurposed hexestrol (HXS) as an antibacterial agent to fight planktonic and biofilm-related MRSA infections. HXS is a nonsteroidal synthetic estrogen that targets estrogen receptors (ERα and ERβ) and has been used as a hormonal antineoplastic agent.
View Article and Find Full Text PDF[Simultaneous determination of nine estrogens in bullfrogs using filtered solid phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry].
Se Pu
July 2022
Ningbo Municipal Center for Disease Control and Prevention, Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang Province, Ningbo 315010, China.
Due to the harmful effects of estrogens and their prevalence in animal foods, accurate analysis of estrogen levels in animal foods is imperative in order to effectively assess food safety risks and ensure consumer safety. Therefore, a rapid and accurate method based on PRiME HLB solid phase extraction (SPE) cartridge purification and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed to determine nine estrogen residues in bullfrogs. The nine estrogens included estriol (E3), 17-estradiol (-E), 17-estradiol (-E), 17-ethinylestradiol (EE2), estrone (EI), diethylstilbestrol (DES), dienestrol (DE), hexestrol (HEX), and dienestrol diacetate (DD).
View Article and Find Full Text PDFEffect-directed analysis of estrogenic chemicals in sediments from an electronic-waste recycling area.
Environ Pollut
August 2022
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China; College of Environmental and Resource Science, Zhejiang University, Hangzhou, 310058, China; Institute of Environment and Health, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310000, China.
Electronic waste (e-waste) pollution is of great concern due to the release of hazardous chemicals during the improper e-waste disposal. Many chemicals leached from e-waste were reported to pose estrogenic effects. To date, little is known regarding the occurrence and biological effects of estrogenic chemicals in sediments near an e-waste area.
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