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Incidence of mycobacteria in pulmonary granulomatous lesions.
Clinics (Sao Paulo)
December 2024
Hospital Sírio Libanês, São Paulo, SP, Brazil.
Mycobacteria infections are caused by species of the Mycobacterium tuberculosis complex (MTB) and other species called Non-Tuberculosis Mycobacteria (NTM). Identification of mycobacteria species is very important to define treatment and it can be achieved by direct culture. However, the lack of clear protocols regarding the use of culture or molecular tests on specimens diagnosed with granulomatous lesions causes delays in the diagnosis of the etiological agents and, consequently, the definition of the right treatment.
View Article and Find Full Text PDFCost-effectiveness of integrating paediatric tuberculosis services into child healthcare services in Africa: a modelling analysis of a cluster-randomised trial.
BMJ Glob Health
December 2024
Division of Population Health, The University of Sheffield, Sheffield, UK.
Background: In 2021, over one million children developed tuberculosis, resulting in 214 000 deaths, largely due to inadequate diagnosis and treatment. The diagnosis and treatment of tuberculosis is limited in most high-burden countries because services are highly centralised at secondary/tertiary levels and are managed in a vertical, non-integrated way. To improve case detection and treatment among children, the World Health Organisation (WHO) recommends decentralised and integrated tuberculosis care models.
View Article and Find Full Text PDFMaternal Health Planning and Prioritization in Chad: Developing a supportive tool.
Health Policy Plan
December 2024
Professor Global Health, Department of International Public Health, Liverpool School of Tropical Medicine; Department of Obstetrics and Gynaecology, University of Nairobi, Kenya.
The Republic of Chad has one of the highest rates of maternal mortality in the world. With scarce resources to respond to competing demands, pragmatic evidence-based planning tools are needed to aid planning and support priority setting. This action research aimed to develop a tool to support maternal health (MH) planning and prioritization decisions and identify priority regions/provinces for intervention in Chad based on aggregate MH coverage gap scores (Target-Coverage=Coverage Gap).
View Article and Find Full Text PDFpseudo-outbreak due to laboratory cross-contamination: A molecular epidemiology outbreak investigation.
Can Commun Dis Rep
December 2024
Immunopathology Axis, Centre de recherche du Centre hospitalier de l'Université de Montréal, Montréal, QC.
Background: Mycobacterial culture is routinely performed to diagnose tuberculosis (TB) in Canada. Globally, meta-analyses suggest that up to 2% of positive cultures are falsely positive for due to laboratory cross-contamination. Five patients from distinct clinical institutions in Montréal were diagnosed with culture-positive TB as their clinical samples were processed in a centralized mycobacteria laboratory.
View Article and Find Full Text PDFApplication of Monoclonal Anti-Mycolate Antibodies in Serological Diagnosis of Tuberculosis.
Trop Med Infect Dis
November 2024
Future Production: Chemicals, Council for Scientific and Industrial Research, Pretoria 0081, South Africa.
Article Synopsis
- - Patient loss to follow-up due to expensive and centralized diagnostics for tuberculosis is a major challenge, stressing the need for a more accessible testing method.
- - Current biomarkers, specifically antibodies against mycolic acids in mycobacterial cell walls, show potential but are hard to detect with typical rapid tests because they are of low affinity.
- - Researchers have developed a new method for detecting mycolic acid antibodies using engineered monoclonal antibodies, leading to the creation of a novel lateral flow immunoassay called MALIA, which shows promise for practical tuberculosis testing.
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