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Effects of Infant Formula Supplemented With Prebiotics on the Gut Microbiome, Gut Environment, Growth Parameters, and Safety and Tolerance: A Systematic Review and Meta-Analysis.
Nutr Rev
January 2025
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, United States.
Context: Prebiotics are often added to infant formulas to mimic the benefits of oligosaccharides found in human milk.
Objective: This systematic review and meta-analysis evaluated the effects of prebiotic-supplemented cow's milk-based formula on the gut microbiota, gut environment, growth parameters, and safety and tolerance in infants ≤6 months old, compared with a standard formula or human milk comparator.
Data Sources: Searches were performed in the PubMed, Embase, Cochrane Central Register of Controlled Trials, and ProQuest Dissertations & Theses databases.
Quantification and prediction of human fetal (-)-Δ-tetrahydrocannabinol/(±)-11-OH-Δ-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity.
Nat Commun
January 2025
Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, WA, USA.
Prenatal cannabis use is associated with neurodevelopmental deficits, likely due to exposure to the psychoactive cannabinoid, (-)-Δ-tetrahydrocannabinol, and its active metabolite, (±)-11-OH-Δ-tetrahydrocannabinol. To determine causality, preclinical studies mimicking human fetal cannabinoid exposure must be conducted. Here we show cannabinoid concentrations across gestation in maternal plasma and paired fetal tissues in trimester 1 and 2 and maternal plasma and fetal umbilical venous plasma in trimester 3.
View Article and Find Full Text PDFPGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity.
Proc Natl Acad Sci U S A
December 2024
Department of Microbiology Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.
Adenocarcinomas from multiple tissues can converge to treatment-resistant small cell neuroendocrine (SCN) cancers composed of ASCL1, POU2F3, NEUROD1, and YAP1 subtypes. We investigated how mitochondrial metabolism influences SCN cancer (SCNC) progression. Extensive bioinformatics analyses encompassing thousands of patient tumors and human cancer cell lines uncovered enhanced expression of proliferator-activatedreceptor gamma coactivator 1-alpha (PGC-1α), a potent regulator of mitochondrial oxidative phosphorylation (OXPHOS), across several SCNCs.
View Article and Find Full Text PDFMoritz Nagel (1808-1871): A faceless name in the history of the adrenal glands.
J Med Biogr
November 2024
Department of Biomedical Sciences, School of Medicine, University of Padova, Padova, Italy.
In 1836, an article was published in which the terms (cortical substance) and (medullary substance) were introduced for the first time with reference to the adrenal glands. The author was indicated as 'Dr Nagel', without any further specification. Modern scientific literature often identifies the author's name as 'N.
View Article and Find Full Text PDFRefining the implementation research logic model: a citation analysis, user survey, and scoping review protocol.
Front Health Serv
October 2024
Department of Population Health Sciences, Division of Health System Innovation and Research, Spencer Fox Eccles School of Medicine at The University of Utah, Salt Lake City, UT, United States.
Introduction: The Implementation Research Logic Model (IRLM) aids users in combining, organizing, and specifying the relationships between important constructs in implementation research. The goal of the IRLM is to improve the rigor, reproducibility, and transparency of implementation research projects. The article describing the IRLM was published September 25, 2020 (, Vol 15); it has since been highly cited and included as a required element in multiple funding opportunity announcements from federal agencies.
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