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Discrimination by SZL49 between contractions evoked by noradrenaline in longitudinal and circular muscle of human vas deferens.
Br J Pharmacol
May 2002
GKT School of Biomedical Sciences, King's College London, Guy's Campus, London SE1 1UL, UK.
The effects of irreversible alpha1-adrenoceptor antagonists, SZL-49 (an alkylating analogue of prazosin), dibenamine and benextramine on contractions to noradrenaline (NA) in longitudinal and circular muscle of human epididymal vas deferens were investigated. Competitive alpha1-adrenoceptor antagonists were also used to further characterize the alpha1-adrenoceptor subtype stimulated by NA in longitudinal and circular muscle. NA evoked concentration-dependent contractions of both muscle types (pD2; 5.
View Article and Find Full Text PDFPhysiological color change in the bullfrog, Rana catesbeiana.
J Exp Zool
February 1999
Departamento de Fisiologia, Universidade de São Paulo, Brasil.
Adults of Rana catesbeiana maintained for 4 days in 12:12 light/dark regimen exhibited a rhythmic color change of 24 hr. Under constant light, however, the rhythm disappeared, and the reflectance values gradually became greater, that is the animals became lighter. Under constant darkness, the rhythm was also abolished, but the animals tended to a darker color.
View Article and Find Full Text PDF1. A method is described for measuring continuously the efflux of potassium or rubidium from smooth muscle of the guinea-pig. 2.
View Article and Find Full Text PDFActions of galanin and some of its analogues on rat isolated gastric fundus.
Fundam Clin Pharmacol
February 1997
Department of Pharmacology, Medical University of Gdańsk, Gdańsk-Wrzeszcz, Poland.
The study was undertaken to characterize the effects of porcine galanin (pGal) and some of its analogues on rat gastric fundus muscle strips. pGal, galantide (M15) and pGal(1-14)-[Abu8]SCY-I evoked reproducible concentration-dependent contractions in concentrations of 1-300, 3-1,000 and 100-3,000 nM, respectively, with EC50 values of 13, 70 and 187 nM. Hill's coefficient for pGal is 1.
View Article and Find Full Text PDFInteractions between responses mediated by activation of adenosine A2 receptors and alpha 1-adrenoceptors in the rabbit isolated aorta.
Br J Pharmacol
June 1993
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York 11439.
1. This paper describes aspects of the functional antagonism between the responses mediated by activated alpha 1-adrenoceptors and adenosine A2 receptors in the adventitia- and endothelium-denuded aorta of the rabbit. 2.
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