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Introduction: Influenza A (H1N1) virus was first reported on April 2009 and, since then, several studies have reported the characteristics concerning the clinical presentation and pulmonary involvement. However, accurate information about the acute kidney injury (AKI) and kidney histopathological findings in these patients remain scarce.
Objective: To describe the kidney histopathological findings of 6 patients with H1N1 who developed AKI and underwent kidney biopsy, correlating them with clinical features.
Renal morphologic lesions reminiscent of diabetic nephropathy.
Arch Pathol Lab Med
March 2013
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611, USA.
Context: Nodular, intercapillary glomerulosclerotic lesions resembling Kimmelstiel-Wilson nodules commonly observed in diabetic nephropathy can also be seen in patients without any clinical history or evidence of diabetes.
Objectives: To discuss the pathobiology of lesions reminiscent of diabetes nephropathy, including light-chain deposition disease, amyloidosis, immunotactoid nephropathy, the membranoproliferative form of glomerulonephritis, and idiopathic nodular glomerulosclerosis, and how to differentiate them from diabetic nephropathy.
Data Sources: Published literature and authors' personal experience.
Isolation and propagation of glomerular mesangial cells.
Methods Mol Biol
February 2009
Division of Nephrology, Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy.
Cultures of glomerular mesangial cells (MC) of rodent or human origin have been extensively employed in renal research laboratories since the early 1980s. Cultured MC retain extensive analogies with the fairly undifferentiated in vivo phenotype of an intercapillary mesenchymal cell population, i.e.
View Article and Find Full Text PDF[The classics of Italian nephrology: the monograph "La nefropatia diabetica" (Diabetic nephropathy) by Luigi Scapellato (1918-1998)].
G Ital Nefrol
April 2016
U.O. di Nefrologia, Dialisi e Trapianto, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano - Italy.
This monograph, published in 1953, describes the findings observed by the author in a cohort of patients affected by diabetes mellitus and renal disease. From a pathological standpoint, the typical renal lesion is represented by ''nodular intercapillary glomerulosclerosis'', which is present in 8 out of 20 patients at postmortem. Marked proteinuria and edema are the most typical clinical features.
View Article and Find Full Text PDFAllograft diabetic nephropathy may progress to end-stage renal disease.
Pediatr Transplant
August 2004
Departments of Medicine, Surgery and Pathology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Box 52, Brooklyn, NY 11203, USA.
Mesangial expansion and glomerular basement membrane thickening characteristic of diabetic nephropathy recur in diabetic recipients of renal allografts from non-diabetic donors but progression to renal failure is minimally documented. Three female renal allograft recipients (aged 40, 62 and 73 yr), who developed end-stage renal disease (ESRD) due to recurrent diabetic nephropathy (two patients) and de novo diabetes (one patient) are reported. Onset of proteinuria, uncontrolled hypertension, azotemia, renal allograft pathologic findings and the need for hemodialysis were analyzed.
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