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Pulmonary alveolar proteinosis: Clinical and morphological overview of a rare disease associated with macrophage dysfunction.
Gen Physiol Biophys
January 2025
Institute of Histology and Embryology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
Pulmonary alveolar proteinosis (PAP) is a rare disease characterised by excessive accumulation of surfactant components in alveolar macrophages, alveoli, and peripheral airways. The accumulation of surfactant is associated with only a minimal inflammatory response but can lead to the development of pulmonary fibrosis. Three clinical forms of PAP are distinguished - primary, secondary and congenital.
View Article and Find Full Text PDFTuberculous meningitis-related ischemic stroke: A retrospective study from a tertiary care hospital.
J Clin Tuberc Other Mycobact Dis
February 2025
Department of Neurology, First Affiliated Hospital of Guangxi Medical University, China.
Background: Patients with tuberculous meningitis (TBM) are at high risk of ischemic stroke, and stroke is a poor prognosticator of TBM. However, reports regarding the predictors of stroke in TBM patients are scanty. The aim of this study was to investigate the clinical characteristics and predictors of tuberculous meningitis-related ischemic stroke (TBMRIS).
View Article and Find Full Text PDFA simplified pyrazinamidase test for pyrazinamide antimicrobial susceptibility testing.
J Clin Microbiol
December 2024
Tuberculosis Research Center, Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan.
Unlabelled: Pyrazinamide (PZA) is an important first-line drug for tuberculosis (TB) treatment by eradicating the persisting complex (MTBC). Due to cost and technical challenges, end TB strategies are hampered by the lack of a simple and reliable culture-based PZA antimicrobial susceptibility testing (AST) for routine use. We initially developed a simplified chromogenic pyrazinamidase (PZase) test in the TB reference laboratory using a training set MTBC isolates with various drug-resistant profiles, and validated its performance using consecutive BACTEC MGIT 960 (MGIT)-culture-positive culture in 10 clinical laboratories.
View Article and Find Full Text PDFTuberculosis: A Silent Intruder in the Musculoskeletal Landscape of the Upper Extremity.
Cureus
September 2024
Department of Orthopaedics, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Article Synopsis
- Tuberculosis (TB) can infect various body parts, including the musculoskeletal system, but its symptoms often resemble other conditions, making diagnosis challenging.
- A study focused on four patients with TB in their upper extremities, highlighting the typical symptoms, diagnosis delays, and effective treatment options.
- All patients received anti-TB drug combinations, splinting, and physiotherapy, resulting in complete recovery; timely biopsy for diagnosis was emphasized to improve treatment outcomes.
Genital tuberculosis masquerading as hematometra in an adolescent girl with an acute abdomen: A case report.
Niger Med J
September 2024
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences (AIIMS), Bilaspur (H.P), India.
Childhood and adolescent TB is a silent epidemic. The occurrence of genital tuberculosis (TB) in adolescent girls is rare. This condition is easily misdiagnosed owing to its non-specific clinical presentation that mimics different gynecological or non-gynecological pathologies.
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