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DNA dendrimer-based nanocarriers for targeted Co-delivery and controlled release of multiple chemotherapeutic drugs.
RSC Adv
January 2025
School of Physical Sciences, Great Bay University Dongguan 523000 China
DNA-based nanomaterials have attracted increasing attention over the past decades due to their incomparable programmability and functionality. In particular, dendritic DNA nanostructures are ideal for constructing drug carriers due to their highly branched structure. In this study, an intelligent drug delivery system was constructed based on DNA dendrimers, in which the DNA duplexes were utilized for simultaneously loading both hydrophilic and hydrophobic small molecule drugs.
View Article and Find Full Text PDFStatistical-based detection of pilot contamination attack for NOMA in 5G networks.
Sci Rep
January 2025
Department of Information Technology, Faculty of Computers and Information, Assiut University, Assiut, Assiut, 71515, Egypt.
Fifth-generation (5G) communication technologies, such as millimeter wave communication, massive multiple-input-multiple-output and non-orthogonal-multiple-access (NOMA) are playing a pivotal role in promoting the modern applications of the Internet-of-Things. Using non-orthogonal resource allocation, NOMA can increase spectrum efficiency and achieve wide connectivity with low transmission delay and signaling cost. Despite the high potential of NOMA in 5G communications, NOMA is susceptible to a pilot contamination attack (PCA), in which an attacker resents the same pilot signals as authorized users.
View Article and Find Full Text PDFNoncanonical inhibition of topoisomerase II alpha by oxidative stress metabolites.
Redox Biol
January 2025
University of Chicago, Department of Molecular Genetics and Cell Biology, 929 E. 57th Street, Chicago, IL, 60637, USA. Electronic address:
During its catalytic cycle, the homodimeric ATPase topoisomerase II alpha (TOP2A) cleaves double stranded DNA and remains covalently bound to 5' ends via tyrosine phosphodiester bonds. After passing a second, intact duplex through, TOP2A rejoins the break and releases from the DNA. Thereby, TOP2A can relieve strain accumulated during transcription, replication and chromatin remodeling and disentangle sister chromatids for mitosis.
View Article and Find Full Text PDFProlonged sitting is not associated with altered shear-mediated dilation of the internal carotid artery, despite impairing lower limb endothelial function.
Physiol Rep
February 2025
Department of Biomedical Engineering, Toyo University, Saitama, Japan.
The present study aims to examine the effect of 4 h of continuous sitting on cerebral endothelial function, which is a crucial component of cerebral blood flow regulation. We hypothesized that 4 h of sitting may impair cerebral endothelial function similarly to how it affects lower limb vasculature. Thirteen young, healthy participants were instructed to remain seated for 4 h without moving their lower limbs.
View Article and Find Full Text PDFFibromuscular Dysplasia Clinical Phenotype Manifesting as a Distal Spontaneous Coronary Artery Dissection in a Middle-Aged Man.
Cureus
January 2025
Internal Medicine, University of Florida College of Medicine, Gainesville, USA.
Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease of medium-sized arteries that causes abnormal cellular growth in arterial walls and most commonly affects young to middle-aged women (20-50 years of age). While FMD often involves the renal arteries, it can affect any arterial bed. FMD has a characteristic angiographic appearance of a "string of beads.
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