The Hellp's syndrome is a complication of gravidic hypertension which associates the microangiopathic hemolysis, the cytolytic hepatic anomalies and a thrombocytopenia. There are resemblences between the biologic and histologic forms of the thrombotic microangiopathy and Hellp's syndrome. In this publishing, we report one case of Hellp's syndrome which the particular character is that the hepatic and hemolytic biologic anomalies are still very discrete, where as the thrombopenia is deep; this led us to rediscuss about the authencity of Hellp's syndrome. A neurologic complication, particulary gravissim, is noticed in one case, it concerns the intracerebral hematoma with left deficiency syndrome.
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Identifying new potential genetic biomarkers for HELLP syndrome using massive parallel sequencing.
Pregnancy Hypertens
October 2020
Center For Research in Genetics and Genomics-CIGGUR, GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; Inserm U1016, CNRS UMR8104, Institut Cochin, équipe FGTB, 24, rue du faubourg Saint-Jacques, 75014 Paris, France; Orphan Diseases Group, Biopas Laboratoires, Bogotá, Colombia. Electronic address:
Background: Preeclampsia (PE) is a frequently occurring multisystemic disease affecting ~5% of pregnancies. PE patients may develop HELLP syndrome (haemolysis, elevated liver enzymes, and low platelet), a mother and foetus life-threatening condition. Research into HELLP's genetic origin has been relatively unsuccessful, mainly because normal placental function and blood pressure regulation involve the fine-regulation of hundreds of genes.
View Article and Find Full Text PDFMilestones in the quest for best management of patients with HELLP syndrome (microangiopathic hemolytic anemia, hepatic dysfunction, thrombocytopenia).
Int J Gynaecol Obstet
June 2013
Division of Maternal-Fetal Medicine and Obstetrics, The University of Mississippi Medical Center, Jackson, MS, USA.
In the 3 decades since the original description and naming of the dangerous pregnancy complication called HELLP syndrome, many milestones have been passed in pursuit of a better understanding of the disorder and its best management. It is worthwhile to review the milestones through which we have passed internationally in obstetrics as the peril that this disorder poses to pregnancy has been exposed. Factors of importance for emphasis will be definitions, reasons why the triple classification system impacts practice, the important role glucocorticoids have in reversing the pathogenesis of the disorder if used early, the excellent results reported for mothers when all components of the Mississippi Protocol are utilized for patient care, and the place of plasma exchange in special situations.
View Article and Find Full Text PDF[An unusual case of HELLP syndrome].
Rev Fr Gynecol Obstet
November 1992
Service d'anesthésie réanimation CHU Ibn Rochd Casablanca, Maroc.
The Hellp's syndrome is a complication of gravidic hypertension which associates the microangiopathic hemolysis, the cytolytic hepatic anomalies and a thrombocytopenia. There are resemblences between the biologic and histologic forms of the thrombotic microangiopathy and Hellp's syndrome. In this publishing, we report one case of Hellp's syndrome which the particular character is that the hepatic and hemolytic biologic anomalies are still very discrete, where as the thrombopenia is deep; this led us to rediscuss about the authencity of Hellp's syndrome.
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