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Seizures and premature death in mice with targeted Kv1.1 deficiency in corticolimbic circuits.
Brain Commun
January 2025
Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA.
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related death, likely stemming from seizure activity disrupting vital brain centres controlling heart and breathing function. However, understanding of SUDEP's anatomical basis and mechanisms remains limited, hampering risk evaluation and prevention strategies. Prior studies using a neuron-specific conditional knockout mouse model of SUDEP identified the primary importance of brain-driven mechanisms contributing to sudden death and cardiorespiratory dysregulation; yet, the underlying neurocircuits have not been identified.
View Article and Find Full Text PDFA Case of Primary Aldosteronism Masquerading as Bartter and Gitelman Syndromes.
Cureus
December 2024
Department of Medicine, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, IND.
Primary aldosteronism (PA) is a common cause of secondary hypertension, with familial hyperaldosteronism (FH) contributing to a lesser number of cases. FH type IV, a rare subtype, has hardly been reported as a subtype of PA cases. We present a case of a 27-year-old female who presented to the emergency department with circumoral tingling and numbness.
View Article and Find Full Text PDFFoliar application of nitrates limits lead uptake by Cucumis sativus L. plants.
J Trace Elem Med Biol
January 2025
Department of Molecular Plant Physiology, Institute of Environmental Biology, Faculty of Biology, University of Warsaw, Ilji Miecznikowa 1, Warszawa 02-096, Poland.
Lead is a toxic heavy metal, which accumulates in the soil and is readily absorbed by plant roots. The uptake of toxic elements by crops is a serious threat to human health. For this reason, it is important to prevent the incorporation of heavy metals into the food chain.
View Article and Find Full Text PDFInductively Coupled Plasma Mass Spectrometry Performance for the Measurement of Key Serum Minerals: A Comparative Study With Standard Quantification Methods.
J Clin Lab Anal
December 2024
Department of Urology, Institute of Medicine University of Tsukuba, Tsukuba, Japan.
Background: Inductively coupled plasma mass spectrometry (ICP-MS) is widely used for the accurate measurement of minerals. However, its application to serum essential mineral measurement has not been fully evaluated. The present study aimed to assess the performance of ICP-MS for serum minerals by comparing its measurements to those obtained using standard quantification methods.
View Article and Find Full Text PDFPotassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
JAMA Cardiol
December 2024
Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Importance: Nitric oxide deficiency may contribute to exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF). Prior pilot studies have shown improvements in exercise tolerance with single-dose and short-term inorganic nitrate administration.
Objective: To assess the impact of chronic inorganic nitrate administration on exercise tolerance in a larger trial of participants with HFpEF.
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