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In-depth screening of pesticide exposure in children from urban and agricultural settings in Poland.
Sci Total Environ
January 2025
Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Catalonia, Spain.
The widespread occurrence of pesticides requires thorough evaluations of human population exposure to these chemicals, particularly children, because of the potential long-term effects of some of these neurotoxicants. The present study describes an in-depth screening of 15 pesticides including organophosphates, pyrethroids, carbamates, triazoles, neonicotinoids and their main metabolites. Internal exposure of 7-9-year-old children from urban and agricultural locations in Poland (n = 399) has been studied.
View Article and Find Full Text PDFEarly Initiation of Bundle Sheath Cells During Leaf Development as Visualised by SCARECROW Expression in Dicotyledonous C Plants.
Plant Cell Environ
January 2025
Department of Ecology & Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.
The C type of dicotyledonous plants exhibit a higher density of reticulate veins than the C type, with a nearly 1:1 ratio of mesophyll cells (MCs) to bundle sheath cells (BSCs). To understand how this C-type cell pattern is formed, we identified two SCARECROW (SCR) genes in C Flaveria bidentis, FbSCR1 and FbSCR2, that fully or partially complement the endodermal cell layer-defective phenotype of Arabidopsis scr mutant. We then created FbSCRs promoter β-glucuronidase reporter (GUS) lines of F.
View Article and Find Full Text PDFPromoter analysis reveals conserved 30-base-pair core sequences controlling the nonhair-cell preferential expression of WEREWOLF in Arabidopsis.
Biochem Biophys Res Commun
January 2025
Department of Systems Biology, Yonsei University, Seoul, 03722, Republic of Korea. Electronic address:
The root epidermis of Arabidopsis (Arabidopsis thaliana) consists of two distinct cell types: hair (H) cells and non-hair (N) cells, whose patterning is regulated by a network of genes. Among these, the WEREWOLF (WER) gene, encoding an R2R3 MYB transcription factor, acts as a master regulator by promoting the expression of key downstream genes, such as GLABRA2 and CAPRICE. However, the mechanisms controlling WER expression have remained largely unexplored.
View Article and Find Full Text PDFAssociation of α-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study.
Transl Psychiatry
December 2024
School of Psychiatry, North Sichuan Medical College, Nanchong, China.
This study examines α-klotho levels in depressed American adults and their association with cardiovascular disease and all-cause mortality, utilizing data from the National Health and Nutrition Examination Survey (2007-2016) and mortality details from the National Death Index up to December 31, 2019. Including 3329 participants with depression, findings revealed 485 all-cause and 113 cardiovascular deaths. To investigate the nonlinear association between α-klotho and mortality, the Cox proportional hazards regression model, restricted cubic splines, and two-piecewise Cox proportional hazards model were developed.
View Article and Find Full Text PDFFasting recovers age-related hypertension in the rats: reset of renal renin-angiotensin system components and klotho.
BMC Nephrol
December 2024
Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Article Synopsis
- The study examined how intermittent fasting impacts age-related high blood pressure and the renal renin-angiotensin system in rats.
- Older rats showed higher blood pressure and hormone levels associated with hypertension compared to younger rats, as well as lower levels of α-klotho and kidney receptor proteins.
- Intermittent fasting, especially every other day fasting, effectively lowered blood pressure and improved certain RAS components in older rats, indicating its potential benefits for managing age-related hypertension.
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