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Coadministration of FTY720 and rt-PA in an experimental model of large hemispheric stroke-no influence on functional outcome and blood-brain barrier disruption.
Exp Transl Stroke Med
October 2013
Department of Neurology, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Background: Systemic thrombolysis with recombinant tissue plasminogen activator (rt-PA) is the standard of acute stroke care. Its potential to increase the risk of secondary intracerebral hemorrhage, especially if administered late, has been ascribed to its proteolytic activity that has detrimental effects on blood-brain barrier (BBB) integrity after stroke. FTY720 has been shown to protect endothelial barriers in several disease models such as endotoxin-induced pulmonary edema and therefore is a promising candidate to counteract the deleterious effects of rt-PA.
View Article and Find Full Text PDFNumbness in clinical and experimental pain--a cross-sectional study exploring the mechanisms of reduced tactile function.
Pain
September 2008
Neurologische Universitätsklinik Mainz, Germany Institut für Physiologie und Pathophysiologie, Mainz, Germany Klinik für Anästhesiologie der Universität Mainz, Germany Lehrstuhl für Neurophysiologie, CBTM, Medizinische Fakultät Mannheim der Universität Heidelberg, Germany.
Pain patients often report distinct numbness of the painful skin although no structural peripheral or central nerve lesion is obvious. In this cross-sectional study we assessed the reduction of tactile function and studied underlying mechanisms in patients with chronic pain and in healthy participants exposed to phasic and tonic experimental nociceptive stimulation. Mechanical detection (MDT) and pain thresholds (MPT) were assessed in the painful area and the non-painful contralateral side in 10 patients with unilateral musculoskeletal pain.
View Article and Find Full Text PDFMicroelectrode study of the genesis of the monophasic action potential by contact electrode technique.
J Cardiovasc Electrophysiol
December 2002
Georgetown University, Washington, DC, USA.
Introduction: Despite widespread use of the contact electrode for recording monophasic action potentials (MAPs) in both clinical and experimental research, the mechanism underlying the genesis of the contact MAP remains unproven. The "Franz hypothesis" assumes that the MAP is driven by a current source originating at the boundary between cells depolarized by the MAP electrode pressure and normal cells immediately adjacent to it. To date, no direct experimental data exist to support this hypothesis.
View Article and Find Full Text PDFImmediate external compression in the management of an acute muscle injury.
Scand J Med Sci Sports
June 1997
Department of Clinical Physiology, Malmö University Hospital, Lund University, Sweden.
In a prospective, non-randomized study 40 athletes with contusion or distension injuries to the thigh or the calf muscle were followed with tests of range of motion (ROM) of knee or ankle joint, test of serum creatine kinase (CK) and ultrasonography of the injury until completely recovered. An experimental group of 19 injuries where subjects received treatment with application of a maximum compression bandage within 5 min (mean = 2 min) of the injury was compared to a control group of 21 injuries where subjects were treated with rest and elevation only, and in some cases non-maximum compression after 10-30 min. No significant differences were noted with respect to time to complete subjective recovery, ultrasonic size of the injury or time to normal findings on ultrasound between treatment and control groups.
View Article and Find Full Text PDFRe-expression of glia-derived nexin/protease nexin 1 depends on mode of lesion-induction or terminal degeneration: observations after excitotoxin or 6-hydroxydopamine lesions of rat substantia nigra.
J Neurosci Res
February 1994
Section of Neuroanatomy, Basel University, Switzerland.
The serine protease inhibitor and neurite outgrowth promoter glia derived nexin (GDN) is expressed in the rat CNS during embryogenesis and persists in the olfactory system of the adult where receptor neurons are replaced throughout life. We investigated whether GDN-immunoreactivity also appears in the adult at sites of synaptic rearrangement following nerve cell death and anterograde terminal degeneration in experimental models for Parkinson's disease. Rat substantia nigra was unilaterally lesioned by stereotaxic application of different toxins: 6-hydroxydopamine, which selectively destroys dopaminergic neurons, the excitotoxic glutamate analog ibotenic acid, or the glutamate receptor agonists N-methyl-D-aspartate and quisqualate, which cause circumscript lesions of the whole substantia nigra.
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