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Early insight into the potential contribution of aluminum to neurodegeneration - A tribute to the research work of Robert D. Terry, Igor Klatzo, Henryk M. Wisniewski and Donald R.C. Mclachlan.
J Inorg Biochem
February 2020
LSU Neuroscience Center, LSU Health Sciences Center, New Orleans, LA 70112, USA; Department of Microbiology, Immunology and Parasitology, LSUHSC, New Orleans, LA 70112, USA; Department of Neurology, LSU Health Sciences Center, New Orleans, LA 70112, USA; Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA 70112, USA. Electronic address:
The first successful attempt to obtain purified aluminum metal was accomplished by the Danish physicist and chemist Hans Christian Orsted in 1824, however it was not until about ~140 years later that aluminum's capacity for neurological disruption and neurotoxicity was convincingly established. The earliest evidence of the possible involvement of this biosphere-rich metallotoxin in Alzheimer's disease (AD) originated in the early-to-mid-1960's from animal and human research investigations that arose almost simultaneously from independent laboratories in the United States and Canada. This short communication pays tribute to the pioneering research work on aluminum in susceptible species, in AD animal models and in AD patients by the early investigators Drs.
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