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A combined 4D flow MR imaging and fluid-structure interaction analysis of ascending thoracic aortic aneurysms.
Biomech Model Mechanobiol
March 2025
Department of Chemical Engineering, Imperial College London, London, UK.
This study aimed to characterize the altered hemodynamics and wall mechanics in ascending thoracic aortic aneurysms (ATAA) by employing fully coupled two-way fluid-structure interaction (FSI) analyses. Our FSI models incorporated hyperelastic wall mechanical properties, prestress, and patient-specific inlet velocity profiles (IVP) extracted from 4D flow magnetic resonance imaging (MRI). By performing FSI analyses on 7 patient-specific ATAA models and 6 healthy aortas, the primary objective of the study was to compare hemodynamic and biomechanical features in ATAA versus healthy controls.
View Article and Find Full Text PDFNon-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis.
Heart
February 2025
Department of Obstetrics and Gynecology, McMaster University Department of Medicine, Hamilton, Ontario, Canada.
Background: Cardiovascular disease is the leading cause of death globally. Non-malignant gynaecological diseases (NMGD) significantly affect patient health and well-being and may be associated with cardiovascular or cerebrovascular disease (C/CVD).
Methods: Seven databases were searched for relevant studies up to 21 April 2024.
Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study.
EClinicalMedicine
January 2025
Leicester Real World Evidence Unit, Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, LE5 4PW, UK.
Background: People with diabetes are at increased risk of hospitalisation, morbidity, and mortality following SARS-CoV-2 infection. Long-term outcomes for people with diabetes previously hospitalised with COVID-19 are, however, unknown. This study aimed to determine the longer-term physical and mental health effects of COVID-19 in people with and without diabetes.
View Article and Find Full Text PDFSecond harmonic generation imaging reveals entanglement of collagen fibers in the elephant trunk skin dermis.
Commun Biol
January 2025
Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.
Form-function relationships often have tradeoffs: if a material is tough, it is often inflexible, and vice versa. This is particularly relevant for the elephant trunk, where the skin should be protective yet elastic. To investigate how this is achieved, we used classical histochemical staining and second harmonic generation microscopy to describe the morphology and composition of elephant trunk skin.
View Article and Find Full Text PDFAliphatic-acid coating and nano chitosan nucleator synergistically regulate the performance of PMMA "bone-Locking" foam dressing used for emergency fixation of clavicle fracture.
Int J Biol Macromol
January 2025
School of Materials Science and Engineering, Xi'an University of Technology, Xi'an 710048, PR China; Shaanxi Province Key Laboratory of Corrosion and Protection, Xi'an University of Technology, Xi'an 710048, PR China. Electronic address:
Clavicle emergency fixation can prevent fractured end from piercing heart and lung organs, which is crucial for wounded life. Clavicle with complex structure, great individual differences, and adjacent to important organs, which places high-requirements on performance of fixation materials. Developing advanced clavicle fixation material is a prominent hot-topic in the field of emergency-engineering.
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