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Therapeutic potential of rutin in premenstrual depression: evidence from and studies.
Front Pharmacol
January 2025
Laboratory of Traditional Chinese Medicine and Stress Injury of Shandong Province, Laboratory Animal Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Introduction: Premenstrual dysphoric disorder (PMDD) is a cyclical mood disorder that severely affects the daily life of women of reproductive age. Most of the medications being used clinically have limitations such as low efficacy, side effects, and high cost, so there is an urgent need to discover safer and more effective medications. Rutin is a natural flavonol glycoside with various pharmacological properties including antidepressant.
View Article and Find Full Text PDFHistopathological characterization of skin and muscle lesions induced by lionfish () venom in a murine experimental model.
J Venom Anim Toxins Incl Trop Dis
January 2025
Department of Biochemistry, School of Medicine, University of Costa Rica, San José, Costa Rica.
Background: Fish venoms have been poorly characterized and the available information about their composition suggests they are uncomplicated secretions that, combined with epidermal mucus, could induce an inflammatory reaction, excruciating pain, and, in some cases, local tissue injuries.
Methods: In this study, we characterized the 24-hour histopathological effects of lionfish venom in a mouse experimental model by testing the main fractions obtained by size exclusion-HPLC. By partial proteomics analysis, we also correlated these effects with the presence of some potentially toxic venom components.
Cholesterol metabolism regulator SREBP2 inhibits HBV replication via suppression of HBx nuclear translocation.
Front Immunol
January 2025
Department of Hepatology, Center for Pathogen Biology and Infectious Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin, China.
The intricate link between cholesterol metabolism and host immune responses is well recognized, but the specific mechanisms by which cholesterol biosynthesis influences hepatitis B virus (HBV) replication remain unclear. In this study, we show that SREBP2, a key regulator of cholesterol metabolism, inhibits HBV replication by interacting directly with the HBx protein, thereby preventing its nuclear translocation. We also found that inhibiting the ER-to-Golgi transport of the SCAP-SREBP2 complex or blocking SREBP2 maturation significantly enhances HBV suppression.
View Article and Find Full Text PDFGolgi protein 73: charting new territories in diagnosing significant fibrosis in MASLD: a prospective cross-sectional study.
Front Endocrinol (Lausanne)
January 2025
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Objectives: To explore the correlation between serum Golgi protein 73 (GP73) levels and the degree of fibrosis in Metabolic dysfunction associated steatotic liver disease (MASLD); to establish a non-invasive diagnostic algorithm based on serum GP73 and liver elasticity.
Methods: This is a prospective cross-sectional study, including 228 patients diagnosed with MASLD from May 2018 to January 2024 at two tertiary hospitals. Clinical data and hepatic pathological features and the correlation between serum GP73 and liver fibrosis were assessed.
The nature of halogen bonding: insights from interacting quantum atoms and source function studies.
IUCrJ
March 2025
Department of Chemistry, Università degli Studi di Milano, via Golgi 19, 20133 Milano, Italy.
A detailed study of the X...
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