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Inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma.
Respirology
January 2025
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia.
Background And Objective: Severe asthma is a heterogeneous disease with subtype classification according to dominant airway infiltrates, including eosinophilic (Type 2 high), or non-eosinophilic asthma. Non-eosinophilic asthma is further divided into paucigranulocytic or neutrophilic asthma characterized by elevated neutrophils, and mixed Type 1 and Type 17 cytokines in the airways. Severe non-eosinophilic asthma has few effective treatments and many patients do not qualify for biologic therapies.
View Article and Find Full Text PDFBackground: Preeclampsia (PE) is a serious inflammatory process that is unique to pregnancy, occurring at or after the 20th week of pregnancy, and leading to maternal and neonatal illness and systemic disruptions. Placental hypoxia leads to increased levels of cytokines and inflammatory syncytiotrophoblast microvillus membrane microparticles (STBM) which activates neutrophils leading to oxidative stress and endothelial dysfunction in preeclampsia. The mechanisms that cause PE in people remain unknown.
View Article and Find Full Text PDFGlobal Burden of Cardiovascular Diseases and Risks, 1990-2022.
J Am Coll Cardiol
December 2023
Department of Health Metrics Sciences, Institute for Health Metrics and Evaluation, School of Medicine, University of Washington, Seattle, Washington, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA. Electronic address:
Gaston Ramon (to Centenary of the discovery of anatoxins).
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
September 2023
The Federal State Autonomous Educational Institution of Higher Education "The Patrice Lumumba Peoples' Friendship University of Russia" of Minobrnauka of Russia (RUDN University), 117198, Moscow, Russia.
In the history of science, there are great scientists who, without being physicians, wrote golden pages in the History of Medicine. Such was Louis Pasteur, founder of scientific microbiology and immunology. Such was his follower Gaston Ramon (1886-1963), French veterinarian and immunologist who created 100 years ago first anatoxin for active prevention of diphtheria and later tetanus and thus opened era of anatoxins (toxoids) - vaccines based on toxin molecule devoid of toxic properties, but preserving immunogenicity and antigenic specificity.
View Article and Find Full Text PDFGPR109A expressed on medullary thymic epithelial cells affects thymic Treg development.
Eur J Immunol
November 2023
Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.
Regulatory T cells (Treg) maintain immune homeostasis due to their anti-inflammatory functions. They can be generated either centrally in the thymus or in peripheral organs. Metabolites such as short-chain fatty acids produced by intestinal microbiota can induce peripheral Treg differentiation, by activating G-protein-coupled-receptors like GPR109A.
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