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Promethazine hydrochloride (PMHC) is a vital drug that is used as an anticholinergic, antipsychotic, antihistaminic, analgesic, sedative, and neuroleptic. However, the overdosage of PMHC also causes reproductive variations, cardiac changes, hypotension, and endocrinal variations. Hence, the detection of PMHC is crucial.

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Article Synopsis
  • Promethazine, often prescribed as a sleep aid, lacks strong evidence for effectiveness and can interfere with better long-term treatments.
  • It poses risks due to its potential for addiction and undesirable side effects, especially in mental health patients.
  • Cognitive-behavioral therapy for insomnia is suggested as a preferred alternative based on guidelines from NICE.
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Health risk assessment of potassium bromate in bread in Ghana.

Heliyon

January 2024

Food Laboratory Department, Food and Drugs Authority, Post Office Box CT2783, Cantonments, Accra, Ghana.

Introduction: Potassium bromate (KBrO) is an oxidizing agent added to flour to improve bread quality. However, KBrO is nephrotoxic, and a class B carcinogen banned in most countries, including Ghana.

Aim: This study aimed to determine the residual KBrO concentration in bread and to estimate the chemical and carcinogenic risk that is associated with the consumption of these breads in Ghana.

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Purpose: Evaluate the effectiveness of various drugs in preventing postdischarge nausea and vomiting (PDNV).

Design: Systematic review.

Methods: A search for evidence was conducted in PubMed, CINAHL, Cochrane Collaboration, and Google Scholar and gray literature.

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Background The presence of psychiatric symptoms in pregnancy is a common occurrence that requires swift and effective management to avoid harm to self, caregivers, staff, and, above all, the reliant fetus. However, there is a dearth of knowledge, practical guidelines, and research in the context of managing agitated states of antenatal patients. To bridge this critical knowledge gap, this research endeavors to illuminate the practices surrounding the management of agitated pregnant women with respect to psychiatric emergencies in a tertiary care hospital.

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