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Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres.
Pathogens
February 2025
Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.
During pregnancy, primary infection can cause congenital toxoplasmosis (CT). We described the newborns' outcomes from a multicentre cohort of mothers with seroconversion (SC) at different gestational ages. This retrospective observational study (from 2007 to 2018) was conducted in two Italian referral hospitals: Fondazione IRCCS Policlinico San Matteo in Pavia and Spedali Civili in Brescia.
View Article and Find Full Text PDF[CONGENITAL TOXOPLASMOSIS: AWARENESS ENABLES PREVENTION, EARLY TREATMENT, AND IMPROVED OUTCOME].
Harefuah
February 2025
Faculty of Medicine, Tel Aviv University, Foetal Neurology Clinic, Department of Obstetrics.
Infection with the intracellular parasite Toxoplasma gondii is a common worldwide infection and is often asymptomatic. A unique risk group that requires identification of such infection is fetuses, and the earlier the infection, the more severe the damage. As pregnancy progresses, the risk of fetal infection increases.
View Article and Find Full Text PDFMjTX-II, a Lys49-PLA from Bothrops moojeni snake venom, restricts Toxoplasma gondii infection via ROS and VEGF regulation.
Chem Biol Interact
March 2025
Laboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. Electronic address:
Owing to the lack of efficient therapy and emerging resistance strains, toxoplasmosis affects about one-third of the world's population. Also, pregnancy-related infection can cause vertical transmission and result in fetal death. Despite the global efforts to combat Toxoplasma gondii infection, conventional therapies have been associated with serious side effects.
View Article and Find Full Text PDFPrevalence and Types of Congenital Anomalies in Singleton Pregnancies at a Tertiary Care Hospital.
Cureus
December 2024
Obstetrics and Gynecology, Shalamar Medical and Dental College, Lahore, PAK.
Introduction Congenital malformations are a major cause of perinatal morbidity and mortality in developing countries and are assuming greater importance than ever before. They affect a variety of organ systems and various etiologies have been identified in literature including Toxoplasmosis, Other (syphilis, varicella-zoster, parvovirus B19), Rubella, Cytomegalovirus, Herpes Simplex (TORCH) infections, exposure to pollutants, consumption of tobacco and alcohol, and advanced maternal age. In developing countries, diagnosis is frequently delayed which leads to poorer outcomes.
View Article and Find Full Text PDFEpidemiological Characteristics and Maternal Risk Factors of Microtia and Aural Atresia in Kazakhstan.
Int Arch Otorhinolaryngol
January 2025
School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Microtia and aural atresia present congenital ear anomalies that affect external ear and are associated with conductive hearing loss. Both anomalies result from exposure to various prenatal risk factors, most common during the first trimester of pregnancy. This study was aimed at epidemiological analysis of microtia/atresia and associated risk factors in the Kazakhstani population.
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