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Feasibility and surgical outcomes of simultaneous urethral reconstruction for synchronous urethral strictures.
Int J Urol
January 2025
Department of Urology, National Defense Medical College, Saitama, Japan.
Objectives: To evaluate the feasibility and surgical outcomes of simultaneous urethral reconstruction for synchronous urethral strictures (SUS) and analyze the surgical techniques employed for different stricture combinations.
Methods: Twenty-two male patients with SUS who underwent urethral reconstruction between February 2018 and July 2023 were retrospectively reviewed. Stricture locations and lengths were evaluated using cystoscopy and urethrography after urethral rest for at least 3 months.
Navigating a Fine Balance: Point-Mutant Cheater Viruses Disrupt the Viral Replication Cycle.
Mol Biol Evol
January 2025
The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv, Israel.
Cheater viruses cannot replicate on their own yet replicate faster than the wild type (WT) when the 2 viruses coinfect the same cell. Cheaters must possess dual genetic features: a defect, which leads to their inability to infect cells on their own, and a selective advantage over WT during coinfection. Previously, we have discovered 2 point-mutant cheaters of the MS2 bacteriophage.
View Article and Find Full Text PDF[Treatment of postoperative complications in cardiothoracic surgery: single-center 10-year experience].
Khirurgiia (Mosk)
December 2024
Petrovsky National Research Center of Surgery, Moscow, Russia.
Objective: To evaluate the results of treatment of postoperative complications in one surgical center over 10 years.
Material And Methods: There were 100 patients with intrapleural complications and indications for surgical correction after various cardiothoracic interventions between 2013 and 2023.
Results: Mortality after thoracoscopic surgeries for cardiothoracic complications was 5%.
Mortality in chronic pulmonary aspergillosis: a systematic review and individual patient data meta-analysis.
Lancet Infect Dis
November 2024
Manchester Fungal Infection Group, University of Manchester, Manchester, UK. Electronic address:
Background: Despite antifungal treatment, chronic pulmonary aspergillosis (CPA) is associated with substantial morbidity and mortality. We conducted a systematic review and meta-analysis to evaluate rates of mortality and its predictors in CPA.
Methods: A systematic literature search was conducted across MEDLINE (PubMed), Scopus, Embase, and Web of Science to identify studies in English, reporting mortality in CPA, from database inception to Aug 15, 2023.
Reassessment of palliative surgery in conversion therapy of previously unresectable hepatocellular carcinoma: Two case reports and review of literature.
World J Gastrointest Surg
October 2024
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
Background: Most patients with hepatocellular carcinoma (HCC) have lost the opportunity for direct surgery at the time of diagnosis. Transarterial chemoembolization (TACE) combined with immune checkpoint inhibitors or tyrosine kinase inhibitors (TKI) can partially transform some unresectable HCC and improve the prognosis effectively. However, based on the promising prospects of combined targeted and immunotherapy for the effective treatment of HCC, the positive role of palliative surgery in the conversion treatment of advanced HCC urgently needs further intensive re-assessment.
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