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Case Reports in the Integration of Technology with Cognitive Rehabilitation for Individuals with Memory Concerns and Their Care Partners.
Arch Clin Neuropsychol
December 2024
Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, SK, S7N 5A5, Canada.
Objective: Technology can be combined with psychological interventions to support older adults with memory concerns. Using a bi-phasic design, cognitive rehabilitation (CR) was integrated with off-the-shelf technology and delivered to two people with cognitive impairment, and one care partner.
Method: Pre- and post-intervention assessments were completed for all participants.
Systems of care that improve outcomes for people with hepatic encephalopathy.
Metab Brain Dis
December 2024
Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
Hepatic encephalopathy (HE) is a critical neuropsychiatric complication of liver cirrhosis with a significant impact on patient quality of life and survival. The global prevalence of cirrhosis and associated HE necessitates a comprehensive understanding of the condition and effective systems of care to optimize outcomes. This review addresses the epidemiology, classification, diagnosis, and management of HE, with an emphasis on systems of care that improve outcomes for people with HE.
View Article and Find Full Text PDFIncrease in beta frequency phase synchronization and power after a session of high frequency repetitive transcranial magnetic stimulation to the primary motor cortex.
Neurotherapeutics
November 2024
Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark. Electronic address:
High-frequency repetitive transcranial magnetic stimulation (rTMS) to the primary motor cortex (M1) is used to treat several neuropsychiatric disorders, but the detailed temporal dynamics of its effects on cortical connectivity remain unclear. Here, we stimulated four cortical targets used for rTMS (M1; dorsolateral-prefrontal cortex, DLPFC; anterior cingulate cortex, ACC; posterosuperior insula, PSI) with TMS coupled with high-density electroencephalography (TMS-EEG) to measure cortical excitability and oscillatory dynamics before and after active- and sham-M1-rTMS. Before and immediately after active or sham M1-rTMS (15 min, 3000 pulses at 10 Hz), single-pulse TMS-evoked EEG was recorded at the four targets in 20 healthy individuals.
View Article and Find Full Text PDFA 40-week phase 2B randomized, multicenter, double-blind, placebo-controlled study evaluating the safety and efficacy of memantine in amyotrophic lateral sclerosis.
Muscle Nerve
January 2025
University of Missouri, Columbia, Missouri, USA.
Article Synopsis
- ALS is a fast-progressing neurodegenerative disease with no cure and limited treatment options, creating a need for better therapies.
- A study was conducted to examine the effects of memantine on ALS progression and related cognitive and behavioral changes using a randomized, placebo-controlled trial with 89 participants.
- Results showed that memantine did not significantly affect the progression of ALS, biomarker changes, or neuropsychiatric symptoms compared to a placebo.
Real-time biopsychosocial antecedents and correlates of functional neurological symptoms in daily life: A pilot remote monitoring technology study.
Psychiatry Res
December 2024
Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom; South London & Maudsley NHS Foundation Trust, United Kingdom.
Article Synopsis
- - Functional Neurological Symptom Disorder (FNSD) involves neurological-like symptoms without a clear neurological cause, and the mechanisms behind it are complex and not fully understood.
- - A study tested the use of remote monitoring technologies (RMT) on 17 individuals with FNS and 17 healthy controls to track symptoms, daily events, and physiological data, finding that those with FNS reported higher levels of negative emotions, pain, and sleep issues.
- - Results indicate that daily stressors and negative feelings significantly impact FNS severity, suggesting that addressing emotional responses could help those with FNS, and calls for larger studies to explore these findings further.
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