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Synthesis and biological evaluation of new dual APN/NEP inhibitors as potent analgesics.
Bioorg Chem
January 2025
School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. Electronic address:
An alternative approach for the management of acute and chronic pains involves prolonging the half-life of endogenous opiates, such as enkephalins that are released in response to nociceptive stimuli. This can be achieved through the inhibition of enzymatic pathways responsible for the hydrolysis of these peptides, particularly targeting Aminopeptidase N (APN) and Neutral Endopeptidase (NEP). In this study, we designed and synthesized a series of dual enkephalinase inhibitors (DENKIs) targeting both APN and NEP as novel analgesic treatments.
View Article and Find Full Text PDFUpcycling of Enzymatically Recovered Amino Acids from Textile Waste Blends: Approaches for Production of Valuable Second-Generation Bioproducts.
ACS Sustain Resour Manag
January 2025
Department of Agrobiotechnology, IFA-Tulln, Institute of Environmental Biotechnology, BOKU University, Vienna, Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria.
Tremendous quantities of textile waste generated and primarily landfilled annually represent a huge risk of contaminating the environment, together with loss of valuable resources. Especially, blended fabrics further pose a challenge for recycling and valorization strategies, while enzymatic hydrolysis offers a highly specific and environmentally friendly solution. In this study, we demonstrate that proteases specifically hydrolyze the wool components in blends with polyester, allowing recovery of pure polyester fibers as well as amino acids and peptides as platform molecules for further valorization.
View Article and Find Full Text PDFChanges of digestive stability and potential allergenicity of high hydrostatic pressure-treated ovalbumin during in vitro digestion.
Food Chem
January 2025
Department of Grain Science and Industry, Kansas State University, Manhattan, KS 66506, USA. Electronic address:
Food allergens are defined by their stability during digestion, with allergenicity largely influenced by resistance to enzymatic hydrolysis. Ovalbumin (OVA), a major egg protein, is a significant contributor to food allergies, particularly in children. Our previous work demonstrated that high hydrostatic pressure (HHP) treatment reduces OVA allergenicity by disrupting conformational epitopes and altering its structure.
View Article and Find Full Text PDFLife cycle of bioethanol production from blends of different food waste.
Environ Technol
February 2025
Technology Institute, University of Passo Fundo, Passo Fundo, RS, Brazil.
Food waste offers a potential source for bioethanol production, but productivity depends on the chemical composition of the raw materials and the processes involved. However, assessment of the environmental sustainability of these processes is often absent and can be carried out using the Life Cycle Assessment (LCA) methodology. This study aimed to perform an LCA on bioethanol production from mixtures of different wastes, including tubers, fruits, and processed foods, focusing on the gate-to-gate phase.
View Article and Find Full Text PDFEffect of Ultrasound Treatment on Structural and Physical Properties of Native Maize Starch.
Plant Foods Hum Nutr
January 2025
Instituto de Ciencia y Tecnología de Alimentos Córdoba (ICYTAC) - CONICET-UNC, Av. Juan Filloy S/N, Ciudad Universitaria, Córdoba, Argentina.
The focus of this work was to evaluate the differences between the thermal and mechanical effects generated by ultrasound waves on the properties of corn starch, which facilitate the subsequent enzymatic hydrolysis for the generation of porous starches. The results showed that both the thermal and mechanical effects have the capacity to disorganize/alter the structure of starch, impacting on its properties. Characteristics such as particle size, pasting and thermal properties (peak viscosity 1400-1800 cp.
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