Glycosaminoglycan (GAG) urine concentrations in syringomyelia patients were much higher than in healthy subjects from January to September. Maximum values of GAG excretion (twice as much as control) in affected patients were observed in spring and summer (from March to July). The results suggest that syringomyelia is accompanied by disorders in GAG connective tissue accumulation.
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Anal Chem
October 2024
Fred Hutchinson Cancer Center, Seattle, Washington 98109, United States.
In cold human blood, the anomalous dynamics of adenosine triphosphate (ATP) result in the progressive accumulation of adenosine diphosphate (ADP), adenosine monophosphate (AMP), inosine monophosphate (IMP), inosine, and hypoxanthine. While the ATP, ADP, AMP, and IMP are confined to red blood cells (RBCs), inosine and hypoxanthine are excreted into plasma/serum. The plasma/serum levels of inosine and hypoxanthine depend on the temperature of blood and the plasma/serum contact time with the RBCs, and hence they represent robust biomarkers for evaluating the preanalytical quality of plasma/serum.
View Article and Find Full Text PDFJ Pharm Bioallied Sci
December 2023
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Maulana Azad University, Jodhpur, Rajasthan, India.
Background: Epilepsy is a neurological disorder characterized by anomalous brain activity, convulsions, and odd behavior. Several substituted-(naphthalen-2-yl)-3-(1H-indol-3-yl) allyl)-1,4-dihydropyridine-4-carboxylic acid derivatives (5a-j) were intended to be produced in the current research effort to reduce convulsions and seizures.
Materials And Methods: The newly developed compounds were produced by the prescribed process.
Cureus
August 2023
Life and Health Sciences Research Institute - ICVS/3B's Associated Laboratory and School of Medicine, University of Minho, Braga, PRT.
Introduction Wilson's disease (WD) is a rare and underdiagnosed genetic disorder caused by anomalous tissue copper deposition, and for which epidemiological studies, specifically in Portugal, are scarce. Objectives This study aimed to evaluate the prevalence and incidence of WD and provide a description of its main clinical and laboratory features. Methods A retrospective study was carried out, with a search between 1995 and 2015, of all patients with a minimum follow-up of three months and birth confirmed in the northern region of Portugal, with an estimated population of 3,689,682 inhabitants.
View Article and Find Full Text PDFChemosphere
January 2023
School of Water Resources and Environment, China University of Geosciences (Beijing), Beijing 100083, PR China.
Roxarsone (3-nitro-4-hydroxyphenylarsonic acid, ROX), widely used as a livestock feed additive, is excreted untransformed in large concentrations. Accumulation of this manure in the open environment increases dissolved organic matter (DOM) and ROX in soil within the aeration zone. And microbial action plays a dominant role in the transformation of ROX.
View Article and Find Full Text PDFCardiovasc Endocrinol Metab
March 2019
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213.
Aims: To evaluate recent trends, by diagnosis year, in the cumulative incidence of vascular type 1 diabetes (T1D) complications and their risk factors up to 35 years duration.
Methods: Participants from the Epidemiology of Diabetes Complications study of childhood-onset T1D were categorized into three calendar year onset cohorts: 1965-69, 1970-74, and 1975-80. All-cause, cardiovascular and renal mortality were determined both on the complete cohort (n=440) as well as in the subset with clinical examinations (n=363).
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