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Both Irritable Bowel Syndrome (IBS) and Gastroesophageal Reflux Disease (GERD) pose significant healthcare burdens on the general population of America. Though first-line medications are available, concomitant burdens of polypharmacy, side effects, and inadequate control exist. Osteopathic Manipulative Treatment (OMT) is a hands-on, physical manipulation technique that offers a personalized and direct approach to modifying the body's neuromuscular and viscerosomatic activity leading to decreased symptomatic burden with minimal side effects.

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Spigelian hernias are rare clinical entities; vague symptomatology and unreliable clinical examination ensure difficult diagnosis. Computed tomography (CT) is critical for accurate diagnosis. Surgical repair is mandated given the high risk of visceral organ incarceration.

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Interactions between top-down attention and bottom-up visceral inputs are assumed to produce conscious perceptions of interoceptive states, and while each process has been independently associated with aberrant interoceptive symptomatology in psychiatric disorders, the neural substrates of this interface are unknown. We conducted a preregistered functional neuroimaging study of 46 individuals with anxiety, depression, and/or eating disorders (ADE) and 46 propensity-matched healthy comparisons (HC), comparing their neural activity across two interoceptive tasks differentially recruiting top-down or bottom-up processing within the same scan session. During an interoceptive attention task, top-down attention was voluntarily directed towards cardiorespiratory or visual signals.

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Predictors and weight impact of postbariatric hypoglycemia after Roux-en-Y gastric bypass surgery: a prospective observational cohort study.

Surg Obes Relat Dis

December 2024

Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland; Service of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

Article Synopsis
  • Postbariatric hypoglycemia (PBH) is a common condition affecting quality of life in patients after Roux-en-Y gastric bypass surgery, with a 32% incidence rate found in a study of 222 patients.
  • Younger age at surgery and experiencing early dumping syndrome are significant predictors of PBH, while higher glucose levels at 2 hours during an oral glucose tolerance test (OGTT) indicate a lower risk.
  • The study found no correlation between PBH and weight changes after surgery, highlighting the complexity of its impact on patients' health outcomes.
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Interoceptive Processing in Functional Gastrointestinal Disorders.

Int J Mol Sci

July 2024

Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.

Functional gastrointestinal disorders (FGIDs) are characterized by chronic gastrointestinal symptoms in the absence of overt pathology and affect a significant percentage of the worldwide population. They are commonly accompanied by co-morbid psychiatric symptomatology and are associated with significant suffering and great healthcare services utilization. There is growing evidence that dysregulation of the gut-brain axis and disturbances in the processing of afferent interoceptive signals lie at the heart of these disorders.

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