Bicarbonate-responsive "soluble" adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172001 | PMC |
| http://dx.doi.org/10.1083/jcb.200311119 | DOI Listing |
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