A rare case of spindle cell lipoma of the knee in a 58-year-old woman is presented. A soft tissue mass on the lateral aspect of the knee, measuring 5 x 6 cm in size, that had been noticed 1 year previously showed slightly lower signal intensities both on T1- and T2-weighted magnetic resonance images than those of subcutaneous adipose tissue. Because pathological findings of the tiny specimen obtained by needle biopsy showed lipogenic tumor and the possibility of well-differentiated liposarcoma could not be ruled out, wide excision was performed. Histopathological examination revealed that the tumor consisted of spindle cells, collagen fibers, and lipocytes. In addition, immunohistochemical study showed positive staining for CD34. From these histological findings, diagnosis of spindle cell lipoma was made. Although expected sites of spindle cell lipoma are the posterior neck, shoulder region, and upper back, it may also arise in the lower extremity. Therefore, when radiological findings suggest lipogenic tumor but are different from those of lipoma, spindle cell lipoma as well as well-differentiated liposarcoma should be considered for differential diagnoses.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00776-003-0745-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ethanolic Extract of Red Okra Pods Induces Aberrant Spindle Segregation and Apoptotic Cell Death by Disrupting the Wnt Signaling Pathway in Colon Cancer Cells.
Iran J Med Sci
December 2024
Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Background: In approximately 80% of colorectal cancer cases, mutations in the adenomatous polyposis coli () gene disrupt the Wingless-related integration site (Wnt)/β-catenin signaling pathway, a crucial factor in carcinogenesis. This disruption may result in consequences such as aberrant spindle segregation and mitotic catastrophe. This study aimed to analyze the effectiveness of the ethanolic extract of red okra () pods (EEROP) in inducing apoptosis in colorectal cancer cells (SW480) by inhibiting the Wnt/β-catenin signaling pathway.
View Article and Find Full Text PDFInvolvement of RBP-J interacting and tubulin-associated protein in the distribution of protein regulator of cytokinesis 1 in mitotic spindles.
Front Cell Dev Biol
January 2025
Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital Frankfurt, J. W. Goethe-University, Frankfurt, Germany.
The protein regulator of cytokinesis 1 (PRC1) is a key regulator of microtubule crosslinking and bundling, which is crucial for spindle formation and cytokinesis. RITA, the BP-J nteracting and ubulin-ssociated protein, is a microtubule associated protein. We have reported that RITA localizes to mitotic spindles modulating microtubule dynamics and stability as well as to spindle poles affecting the activity of Aurora A.
View Article and Find Full Text PDFThe role of Golgi complex proteins in cell division and consequences of their dysregulation.
Front Cell Dev Biol
January 2025
Department of Biomedical Sciences (DSB), Institute of Experimental Endocrinology and Oncology "G. Salvatore" (IEOS), National Research Council (CNR), Naples, Italy.
The GC (Golgi complex) plays a pivotal role in the trafficking and sorting of proteins and lipids until they reach their final destination. Additionally, the GC acts as a signalling hub to regulate a multitude of cellular processes, including cell polarity, motility, apoptosis, DNA repair and cell division. In light of these crucial roles, the GC has garnered increasing attention, particularly given the evidence that a dysregulation of GC-regulated signalling pathways may contribute to the onset of various pathological conditions.
View Article and Find Full Text PDFHigh CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors.
EMBO Rep
January 2025
Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Spindle assembly checkpoint (SAC) inhibitors are a recently developed class of drugs, which perturb chromosome segregation during cell division, induce chromosomal instability (CIN), and eventually lead to cell death. The molecular features that determine cellular sensitivity to these drugs are not fully understood. We recently reported that aneuploid cancer cells are preferentially sensitive to SAC inhibition.
View Article and Find Full Text PDFOvarian Endometrioma Disrupts Oocyte-Cumulus Communication and Mitochondrial Function, With Melatonin Mitigating the Effects.
Cell Prolif
January 2025
Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Ovarian endometrioma (OEM), a particularly severe form of endometriosis, is an oestrogen-dependent condition often associated with pain and infertility. The mechanisms by which OEM impairs fertility, particularly through its direct impact on oocyte-cumulus cell (CC) communication and related pathways, remain poorly understood. This study investigates the impact of OEM on oocyte-CC communication and explores melatonin's therapeutic potential.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!